This paper changed my life

Recent articles

Neuroscientists respond to a set of questions to reflect on a paper that profoundly influenced their career and how they think about their research.

Illustration of birdsong, bird brain, and DNA.

This paper changed my life: Embracing an early model for naturalistic neuroscience

A 1992 PNAS paper showed how birdsong upregulates the expression of an immediate early gene in bird forebrains. The work revealed to Ribeiro the importance of studying molecular responses in naturalistic contexts.

By Sidarta Ribeiro
14 July 2026 | 4 min read
Illustration of cells converting from fibroblasts to myoblasts.

This paper changed my life: Learning the molecular rules of cell identity

A 1987 Cell paper showed that a single transcription factor could turn fibroblasts into muscle cells. The work inspired Ardem Patapoutian to think about the molecular codes that define neuronal subtypes.

By Ardem Patapoutian
17 June 2026 | 6 min read
Neural networks illustration.

This paper changed my life: Appreciating John Hopfield’s brilliant neural network

In a 1982 paper, the Nobel laureate created his namesake recurrent neural network—work that taught Maria Geffen to always ground research questions in biology.

By Maria Geffen
15 May 2026 | 5 min read
Illustration of a monkey pushing a button.

This paper changed my life: Erin Calipari ponders the nuances of rewarding and aversive stimuli

A 1960s study by Kelleher and Morse found that lever pressing in squirrel monkeys depended not on whether they received a reward or shock, but on the rules of the task. This taught Calipari to think deeply about factors that influence how behavior is generated and maintained.

By Erin Calipari
14 April 2026 | 5 min read
Illustration of dopamine neurons.

This paper changed my life: Talia Lerner reflects on dopamine neuron diversity and the value of simple experiments

In a 2011 Neuron study, Stephan Lammel and his colleagues showed that dopamine neurons with different projections have different physiological properties. The work inspired Lerner to think about how to challenge widely held assumptions in the field.

By Talia Lerner
11 March 2026 | 6 min read
Gloved hand reaches out to touch a mouse.

This paper changed my life: Ishmail Abdus-Saboor on balancing the study of pain and pleasure

A 2013 Nature paper from David Anderson’s lab revealed a group of sensory neurons involved in pleasurable touch and led Abdus-Saboor down a new research path.

By Ishmail Abdus-Saboor
13 February 2026 | 7 min read
Illustration of ants marching back to an anthill.

This paper changed my life: John Tuthill reflects on the subjectivity of selfhood

Wittlinger, Wehner and Wolf’s 2006 “stilts and stumps” Science paper revealed how ants pull off extraordinary feats of navigation using a biological odometer, and it inspired Tuthill to consider how other insects sense their own bodies.

By John Tuthill
12 January 2026 | 7 min read
Illustration of human figures holding brightly colored connected dots.

The best of ‘this paper changed my life’ in 2025

From a study that upended astrocyte research to one that reignited the field of spiking neural networks, experts weighed in on the papers that significantly shaped how they think about and approach neuroscience.

By The Transmitter
24 December 2025 | 2 min read
Illustration of a group of neurons.

This paper changed my life: Nancy Padilla-Coreano on learning the value of population coding

The 2013 Nature paper by Mattia Rigotti and his colleagues revealed how mixed selectivity neurons—cells that are not selectively tuned to a stimulus—play a key role in cognition.

By Nancy Padilla-Coreano
1 December 2025 | 5 min read
Abstract illustration of a synaptic vesicle.

This paper changed my life: Sandra Jurado marvels at the first-ever 3D model of a synaptic vesicle

In this 2006 Cell paper, Shigeo Takamori and his colleagues showcased the molecular machinery of synaptic vesicles in outstanding detail. Their work taught me that these aren’t just passive containers for neurotransmitters but dynamic, precision-built nanomachines.

By Sandra Jurado
21 October 2025 | 5 min read

Explore more from The Transmitter

Illustration of scientist facing a fractured landscape.

Redefining underrepresentation in global neuroscience

Shifting the focus of equity initiatives from identity categories to structural barriers can reveal overlooked challenges and increase support and participation worldwide.

Illustration of an open journal featuring lines of text and small illustrations of eyes and mouths.

Separate neuronal pathways mediate social, attentional behaviors

Here is a roundup of autism-related news and research spotted around the web for the week of 20 July.

By Jill Adams
21 July 2026 | 2 min read
Susumu Tonegawa.

In memoriam: Susumu Tonegawa, ‘intellectual giant’

He won the Nobel Prize for his work on immunology and then went on to define the field of learning and memory.

By Claudia López Lloreda
17 July 2026 | 6 min read