This paper changed my life

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Neuroscientists respond to a set of questions to reflect on a paper that profoundly influenced their career and how they think about their research.

Mice playing, engaged in learning and memory: some of their brains are yellow, and some are red, matching a red and yellow legend that runs through the image to underscore both memory and learning.

Este artículo cambió mi vida: Un descubrimiento técnico para estudios de la memoria

En un artículo de Science del 2007, Mark Mayford y sus compañeros encontraron neuronas activadas durante el aprendizaje son reclutadas durante la recuperación de la memoria. Noela Weisstaub comparte como este estudio y otros impulsaron una era de gran progreso en el desarrollo de herramientas

By Noelia Weisstaub
14 August 2026 | 5 min read
Mice playing, engaged in learning and memory: some of their brains are yellow, and some are red, matching a red and yellow legend that runs through the image to underscore both memory and learning.

Este artigo mudou minha vida: um avanço técnico para os estudos da memória

Em um artigo publicado na revista Science em 2007, Mark Mayford e seus colegas descobriram que alguns neurônios ativados durante a aprendizagem também são reativados durante a recuperação da memória. Noelia Weisstaub conta como esse e outros estudos impulsionaram uma era de grande progresso no desenvolvimento de ferramentas.

By Noelia Weisstaub
14 August 2026 | 6 min read
Mice playing, engaged in learning and memory: some of their brains are yellow, and some are red, matching a red and yellow legend that runs through the image to underscore both memory and learning.

This paper changed my life: A technical breakthrough for memory studies

In a 2007 Science paper, Mark Mayford and his colleagues found that some neurons activated during learning are also recruited during memory retrieval. Noelia Weisstaub shares how this study and others drove an era of great progress in tool development.

By Noelia Weisstaub
14 August 2026 | 5 min read
Ilustração de canto de pássaro, cérebro de pássaro e DNA.

Este artigo mudou minha vida: adotando um dos primeiros modelos de neurociência naturalística

Um artigo publicado na PNAS em 1992 mostrou que o canto das aves aumenta a expressão de um gene de resposta imediata no prosencéfalo dessas aves. O estudo revelou a Ribeiro a importância de investigar as respostas moleculares em contextos naturalísticos.

By Sidarta Ribeiro
14 July 2026 | 5 min read
Ilustración del canto de las aves, el cerebro de las aves y el ADN.

Este artículo cambió mi vida: Adoptando un modelo temprano de neurociencia naturalista

Un estudio del 1992 publicado en PNAS demostró que el canto de las aves aumenta la expresión de un gen de respuesta temprana inmediata en el prosencéfalo de los pájaros. El trabajo le reveló a Ribeiro la importancia de estudiar las respuestas moleculares en contextos naturalistas.

By Sidarta Ribeiro
14 July 2026 | 5 min read
Illustration of birdsong, bird brain, and DNA.

This paper changed my life: Embracing an early model for naturalistic neuroscience

A 1992 PNAS paper showed how birdsong upregulates the expression of an immediate early gene in bird forebrains. The work revealed to Ribeiro the importance of studying molecular responses in naturalistic contexts.

By Sidarta Ribeiro
14 July 2026 | 4 min read
Illustration of cells converting from fibroblasts to myoblasts.

This paper changed my life: Learning the molecular rules of cell identity

A 1987 Cell paper showed that a single transcription factor could turn fibroblasts into muscle cells. The work inspired Ardem Patapoutian to think about the molecular codes that define neuronal subtypes.

By Ardem Patapoutian
17 June 2026 | 6 min read
Neural networks illustration.

This paper changed my life: Appreciating John Hopfield’s brilliant neural network

In a 1982 paper, the Nobel laureate created his namesake recurrent neural network—work that taught Maria Geffen to always ground research questions in biology.

By Maria Geffen
15 May 2026 | 5 min read
Illustration of a monkey pushing a button.

This paper changed my life: Erin Calipari ponders the nuances of rewarding and aversive stimuli

A 1960s study by Kelleher and Morse found that lever pressing in squirrel monkeys depended not on whether they received a reward or shock, but on the rules of the task. This taught Calipari to think deeply about factors that influence how behavior is generated and maintained.

By Erin Calipari
14 April 2026 | 5 min read
Illustration of dopamine neurons.

This paper changed my life: Talia Lerner reflects on dopamine neuron diversity and the value of simple experiments

In a 2011 Neuron study, Stephan Lammel and his colleagues showed that dopamine neurons with different projections have different physiological properties. The work inspired Lerner to think about how to challenge widely held assumptions in the field.

By Talia Lerner
11 March 2026 | 6 min read

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Neuronal genes SATB2 and MEF2C.

Nuclear location helps control gene activity during brain development

A study of developing human brain tissue suggests that genes switch on more strongly when they move from the nucleus’s edge toward structures that contain proteins involved in making and processing RNA.

By Giorgia Guglielmi
20 August 2026 | 4 min read
Cortical organoids.

Five-year-old human brain organoids aged on schedule

The cultured spheres typically mimic only prenatal development, but the five-year-old ones grown in Paola Arlotta’s lab acquired postnatal features.

By Claudia López Lloreda
19 August 2026 | 5 min read