Theories of autism

Recent articles

The signaling imbalance theory of autism, explained

The signaling imbalance theory holds that the brains of autistic people are hyper-excitable because of either excess neuronal activity or weak brakes on that activity.

By Sarah DeWeerdt
1 May 2019 | 4 min read

The female protective effect, explained

One of the leading theories of autism posits that girls and women are biologically protected from the condition.

By Hannah Furfaro
1 May 2019 | 4 min read
Illustration of a strong man holding up a oversized brain

The extreme male brain, explained

The ‘extreme male brain’ theory suggests that autism is an exaggeration of systematic sex differences in ways of thinking.

By Hannah Furfaro
1 May 2019 | 5 min read
Illustration of red figures on a big blue brain are serotonin signaling

Serotonin’s link to autism, explained

Serotonin, the brain chemical best known for its link to depression, may also be involved in autism.

By Nicholette Zeliadt
1 May 2019 | 5 min read
A DNA helix showing common and rare variants

The multiple hits theory of autism, explained

Researchers are studying how a combination of genetic ‘hits’ may contribute to autism’s diversity.

By Jessica Wright
1 May 2019 | 4 min read
Illustration shows the world is distorted through a point of view pair of glasses

The predictive coding theory of autism, explained

In autism, a person's brain may not form accurate predictions of imminent experiences, or even if it does, sensory input may override those predictions.

By George Musser
1 May 2019 | 6 min read
overlapping network of connections in the brain

The connectivity theory of autism, explained

A growing body of evidence suggests that autism involves atypical communication between brain regions, but how and where in the brain this plays out is unclear.

By Rachel Zamzow
1 May 2019 | 4 min read

Explore more from The Transmitter

Dendrites help neuroscientists see the forest for the trees

Dendritic arbors provide just the right scale to study how individual neurons reciprocally interact with their broader circuitry—and are our best bet to bridge cellular and systems neuroscience.

By Justin O’Hare
27 February 2026 | 7 min read

Two primate centers drop ‘primate’ from their name

The Washington and Tulane National Biomedical Research Centers—formerly called National Primate Research Centers—say they made the change to better reflect the breadth of research performed at the centers.

By Calli McMurray
26 February 2026 | 5 min read

Post-infection immune conflict alters fetal development in some male mice

The immune conflict between dam and fetus could help explain sex differences in neurodevelopmental conditions.

By Viviane Callier
26 February 2026 | 5 min read

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