Theoretical neuroscience

Recent articles

Illustration of cake with genetic code inside.

The genome offers a recipe, not a blueprint, for the brain

During brain development, genes set the rules and turn the knobs; self-organization does much of the rest.

By Ila Fiete
2 November 2026 | 8 min read
A measuring cup with a whirlpool in it.

When is self-organization a mechanism in brain development?

Retinal waves offer a powerful example of a self-organizing system that can build structure without external guidance. The field would do well to embrace such phenomena more broadly as a type of mechanistic explanation.

By P. Robin Hiesinger
2 November 2026 | 6 min read
Illustration of three steps to build an origami polyhedron.

Dimensionality—neuroscience’s red herring?

Placing too much emphasis on a specific interpretation of dimensionality, or treating it as an end-all quantification of some aspect of neural computation, may hinder progress in understanding the brain.

By Matthew Perich
7 September 2026 | 8 min read

How energy determines where proteins are produced in neurons

Tatjana Tchumatchenko explains how mathematical modeling elucidates whether ion-channel proteins are produced locally in the soma or in the dendrites.

By Gaute Einevoll
26 August 2026 | 104 min listen
Covers of The Transmitter's summer book picks.

Five new neuroscience books, and other notable titles from 2026

The Transmitter’s summer reading list includes an autopsy of the Human Brain Project, an overview of the neuroscience of motherhood and a memoir from a pioneer in Huntington’s disease research.

By Francisco J. Rivera Rosario
25 August 2026 | 7 min read

Reverse engineering neural circuits; success stories from computational neuroscience

Kevin Mitchell talks with Timothy Behrens about ring attractors, the role of innate structure, and an expanded view of cognitive maps.

By Kevin Mitchell
6 August 2026 | 60 min watch
A brain shape outlined in cylindrical dials with multi colored wires stretched between them.

Transforming AI models into useful model organisms

These systems were not built to explain the brain. But treating them as model organisms that we can perturb and evolve will move us closer to that goal.

By Mariya Toneva
22 June 2026 | 6 min read
Illustration of pixelated AI models.

Models at the speed of thought: How AI coding is reshaping theoretical neuroscience

Agentic coding makes it possible to specify a neuroscience model in hours instead of months. Seven neuroscientists weigh in on what that tectonic change may bring to the field.

By Brian DePasquale
16 June 2026 | 17 min read

Romain Brette reveals fundamental flaws in commonly assumed neuroscience concepts

His new book, “The Brain, In Theory,” offers alternatives to many of the computer science frameworks currently driving theoretical neuroscience.

By Paul Middlebrooks
8 April 2026 | 131 min listen

Explore more from The Transmitter

Scans of brains using the OPM-MEG method.

Language development during the first 1,000 days; and more

Here is a roundup of autism-related news and research spotted around the web for the week of 9 November.

By Jill Adams
10 November 2026 | 2 min read
Illustration of brain with many connecting lines.

What ‘Brain Flows’ gets right

Michael W. Cole’s new book makes a convincing case that the dynamic movement of signals underpins just about everything the brain does, though it misses mention of relevant theoretical and single-cell work.

By Daniel Graham
10 November 2026 | 6 min read
Illustration of a binocular view of a hilly path leading towards a temple.

Amid funding uncertainty, graduate neuroscience programs in the U.S. adapt

The Transmitter surveyed 50 graduate program directors to learn how they’re faring. Securing labs for new students is one of the greatest concerns.

By Emily Singer
9 November 2026 | 15 min read