Theoretical neuroscience
Recent articles
The genome offers a recipe, not a blueprint, for the brain
During brain development, genes set the rules and turn the knobs; self-organization does much of the rest.
The genome offers a recipe, not a blueprint, for the brain
During brain development, genes set the rules and turn the knobs; self-organization does much of the rest.
When is self-organization a mechanism in brain development?
Retinal waves offer a powerful example of a self-organizing system that can build structure without external guidance. The field would do well to embrace such phenomena more broadly as a type of mechanistic explanation.
When is self-organization a mechanism in brain development?
Retinal waves offer a powerful example of a self-organizing system that can build structure without external guidance. The field would do well to embrace such phenomena more broadly as a type of mechanistic explanation.
Dimensionality—neuroscience’s red herring?
Placing too much emphasis on a specific interpretation of dimensionality, or treating it as an end-all quantification of some aspect of neural computation, may hinder progress in understanding the brain.
Dimensionality—neuroscience’s red herring?
Placing too much emphasis on a specific interpretation of dimensionality, or treating it as an end-all quantification of some aspect of neural computation, may hinder progress in understanding the brain.
How energy determines where proteins are produced in neurons
Tatjana Tchumatchenko explains how mathematical modeling elucidates whether ion-channel proteins are produced locally in the soma or in the dendrites.
How energy determines where proteins are produced in neurons
Tatjana Tchumatchenko explains how mathematical modeling elucidates whether ion-channel proteins are produced locally in the soma or in the dendrites.
Five new neuroscience books, and other notable titles from 2026
The Transmitter’s summer reading list includes an autopsy of the Human Brain Project, an overview of the neuroscience of motherhood and a memoir from a pioneer in Huntington’s disease research.
Five new neuroscience books, and other notable titles from 2026
The Transmitter’s summer reading list includes an autopsy of the Human Brain Project, an overview of the neuroscience of motherhood and a memoir from a pioneer in Huntington’s disease research.
Marco Facchin explores the ever-shifting landscape of neuroscience theory and philosophy
Computational explanations of cognition, though powerful, aren't the only game in town.
Marco Facchin explores the ever-shifting landscape of neuroscience theory and philosophy
Computational explanations of cognition, though powerful, aren't the only game in town.
Reverse engineering neural circuits; success stories from computational neuroscience
Kevin Mitchell talks with Timothy Behrens about ring attractors, the role of innate structure, and an expanded view of cognitive maps.
Reverse engineering neural circuits; success stories from computational neuroscience
Kevin Mitchell talks with Timothy Behrens about ring attractors, the role of innate structure, and an expanded view of cognitive maps.
Transforming AI models into useful model organisms
These systems were not built to explain the brain. But treating them as model organisms that we can perturb and evolve will move us closer to that goal.
Transforming AI models into useful model organisms
These systems were not built to explain the brain. But treating them as model organisms that we can perturb and evolve will move us closer to that goal.
Models at the speed of thought: How AI coding is reshaping theoretical neuroscience
Agentic coding makes it possible to specify a neuroscience model in hours instead of months. Seven neuroscientists weigh in on what that tectonic change may bring to the field.
Models at the speed of thought: How AI coding is reshaping theoretical neuroscience
Agentic coding makes it possible to specify a neuroscience model in hours instead of months. Seven neuroscientists weigh in on what that tectonic change may bring to the field.
Romain Brette reveals fundamental flaws in commonly assumed neuroscience concepts
His new book, “The Brain, In Theory,” offers alternatives to many of the computer science frameworks currently driving theoretical neuroscience.
Romain Brette reveals fundamental flaws in commonly assumed neuroscience concepts
His new book, “The Brain, In Theory,” offers alternatives to many of the computer science frameworks currently driving theoretical neuroscience.
Explore more from The Transmitter
The term ‘model organism’ should be reserved for biological systems
By referring to artificial neural networks as model organisms, we run the risk of distorting funding priorities and disregard the explanatory power of a shared evolutionary history across biological organisms.
The term ‘model organism’ should be reserved for biological systems
By referring to artificial neural networks as model organisms, we run the risk of distorting funding priorities and disregard the explanatory power of a shared evolutionary history across biological organisms.
New phase of BRAIN Initiative spawns basal ganglia ‘parts list’
With a standardized cell naming system and infrastructure for data collection and analysis, the basal ganglia project sets the stage for a whole-brain primate atlas.
New phase of BRAIN Initiative spawns basal ganglia ‘parts list’
With a standardized cell naming system and infrastructure for data collection and analysis, the basal ganglia project sets the stage for a whole-brain primate atlas.
Machine-learning model spots autism-linked variants that scramble splicing
The model provides a way to investigate genetic variation in regions of the genome whose functions have been difficult to interpret.
Machine-learning model spots autism-linked variants that scramble splicing
The model provides a way to investigate genetic variation in regions of the genome whose functions have been difficult to interpret.