Theoretical neuroscience

Recent articles

A brain shape outlined in cylindrical dials with multi colored wires stretched between them.

Transforming AI models into useful model organisms

These systems were not built to explain the brain. But treating them as model organisms that we can perturb and evolve will move us closer to that goal.

By Mariya Toneva
22 June 2026 | 6 min read
Illustration of pixelated AI models.

Models at the speed of thought: How AI coding is reshaping theoretical neuroscience

Agentic coding makes it possible to specify a neuroscience model in hours instead of months. Seven neuroscientists weigh in on what that tectonic change may bring to the field.

By Brian DePasquale
16 June 2026 | 17 min read

Romain Brette reveals fundamental flaws in commonly assumed neuroscience concepts

His new book, “The Brain, In Theory,” offers alternatives to many of the computer science frameworks currently driving theoretical neuroscience.

By Paul Middlebrooks
8 April 2026 | 131 min listen
Book cover of The Brain, In Theory by Romain Brette.

‘The Brain, In Theory,’ an excerpt

In his new book, Brette pushes back against theories that describe the brain as a “biological computer.” In this excerpt from Chapter 4, he challenges equating brain evolution with programming, and the universality of neural network models.

By Romain Brette
7 April 2026 | 5 min read

What a bird’s-eye view of half a million papers reveals about neuroscience

New research uses artificial-intellligence-driven bibliometrics to map the structural organization of neuroscience across 25 years. The field it reveals is at once thriving and theoretically adrift.

By Mac Shine
6 April 2026 | 36 min watch

Tomaso Poggio on his quest for theories to explain the fundamental learning abilities of brains and machines

Thus far, engineering has outpaced theory in the science of intelligence. But Poggio is hopeful that theories can catch up.

By Paul Middlebrooks
14 January 2026 | 1 min read
Illustration of a simple circuit.

Not playing around: Why neuroscience needs toy models

Amid the rise of billion-parameter models, I argue that toy models, with just a few neurons, remain essential—and may be all neuroscience needs.

By Marcus Ghosh
22 December 2025 | 6 min read
Speech bubbles and images of a brain overlaid on a globe.

A community-designed experiment tests open questions in predictive processing

More than 50 scientists came together to identify the key missing data needed to rigorously test theoretical models.

By Jérôme Lecoq
12 November 2025 | 6 min read
Illustration of a series of floating pools of water overflowing into each other.

The missing half of the neurodynamical systems theory

Bifurcations—an underexplored concept in neuroscience—can help explain how small differences in neural circuits give rise to entirely novel functions.

By Xiao-Jing Wang
27 October 2025 | 8 min read

Ann Kennedy explains the theoretical neuroscience of survival behaviors

The Scripps neuroscientist calls for a broader theoretical neuroscience approach in her area of research, which focuses on how the subcortex bridges life and cognition.

By Paul Middlebrooks
24 September 2025 | 1 min read

Explore more from The Transmitter

Research image of proliferating neural cells.

Diverse autism genes derail common developmental pathways

Multiple genetic mouse models initially show delayed cortical development, but the animals’ molecular trajectories diverge within weeks after birth, a new study finds.

By Holly Barker
8 July 2026 | 5 min read
Brain scans showing sex-based activation differences.

Brain’s sex differences are subtle and contradictory, large MRI study finds

Sex-based behavioral differences do not match with variations in brain activation or structure in a study of almost 1,000 people.

By Lauren Schenkman
8 July 2026 | 5 min read
Research image of autism-linked gene PTEN changes in neurons.

A consensus on the definition of profound autism, and more

Here is a roundup of autism-related news and research spotted around the web for the week of 5 July.

By Sarah Thau
7 July 2026 | 2 min read