The mitochondria candidate: Is the cell’s powerhouse a hidden factor in autism?

Recent articles

Illustration of mitochondria as a kind of Stonehenge, with the shapes standing upright, casting shadows, against a blue sky.

Mitochondria mediate effects of PTEN mutations

Whole-genome sequencing data — which include information about mitochondrial DNA — offer clues to why mutations in the same gene can lead to autism or cancer.

By Katie Moisse
26 June 2023 | 4 min read
lllustration of the junction between two nerve cells.

Multi-omics study captures CNTNAP2’s far-ranging effects

The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.

By Charles Q. Choi
8 December 2022 | 4 min read

Unlocking the mitochondrial genome for autism research

The DNA specific to mitochondria is difficult to access, but new methods place its secrets within reach.

By Laura Dattaro
1 June 2022 | 5 min read
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Mitochondria: An energy explanation for autism

People with autism have more mutations than others do in both mitochondrial DNA and nuclear DNA that affects mitochondrial function.

By Laura Dattaro
22 November 2021 | 3 min watch
Stylized illustration combines flat color and 3D forms make up a mitochondria with human heads inside it.

Meet the ‘mitomaniacs’ who say mitochondria matter in autism

Clues that problems with mitochondria contribute to autism have been accumulating for decades. In the past five years, a mutant mouse and a flurry of findings have energized the field.

By Laura Dattaro
22 November 2021 | 18 min read
Transmission Electron micrograph shows mitochondria colored an aqua blue.

Changes to mitochondrial DNA spur autism-like traits in mice

Mice with a mutation in their mitochondrial DNA show altered brain activity, repetitive behaviors and reduced sociability, according to a new study.

By Laura Dattaro
17 February 2021 | 4 min read

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A repeating pattern of orange butterflies against a blue background.

‘Huge influx’ of neuroscientists migrates to Bluesky

Daily neuroscience-related posts on the social-media platform this week have increased more than 400 percent, on average, compared with October.

By Calli McMurray
21 November 2024 | 5 min read
Woman in a clinician's office.

Autism prevalence increasing in children, adults, according to electronic medical records

The uptick from 2011 to 2022 in the United States underscores a need for more services and research, the investigators say.

By Shaena Montanari
21 November 2024 | 2 min read
Research image of mouse cells.

Immune cell interlopers breach—and repair—brain barrier in mice

The choroid plexus, the protective network of blood vessels and epithelial cells that line the brain’s ventricles, recruits neutrophils and macrophages during inflammation, a new study shows.

By Claudia López Lloreda
20 November 2024 | 6 min read