The mitochondria candidate: Is the cell’s powerhouse a hidden factor in autism?

Recent articles

Illustration of mitochondria as a kind of Stonehenge, with the shapes standing upright, casting shadows, against a blue sky.

Mitochondria mediate effects of PTEN mutations

Whole-genome sequencing data — which include information about mitochondrial DNA — offer clues to why mutations in the same gene can lead to autism or cancer.

By Katie Moisse
26 June 2023 | 4 min read
lllustration of the junction between two nerve cells.

Multi-omics study captures CNTNAP2’s far-ranging effects

The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.

By Charles Q. Choi
8 December 2022 | 4 min read

Unlocking the mitochondrial genome for autism research

The DNA specific to mitochondria is difficult to access, but new methods place its secrets within reach.

By Laura Dattaro
1 June 2022 | 5 min read

Mitochondria: An energy explanation for autism

People with autism have more mutations than others do in both mitochondrial DNA and nuclear DNA that affects mitochondrial function.

By Laura Dattaro
22 November 2021 | 3 min watch
Stylized illustration combines flat color and 3D forms make up a mitochondria with human heads inside it.

Meet the ‘mitomaniacs’ who say mitochondria matter in autism

Clues that problems with mitochondria contribute to autism have been accumulating for decades. In the past five years, a mutant mouse and a flurry of findings have energized the field.

By Laura Dattaro
22 November 2021 | 18 min read
Transmission Electron micrograph shows mitochondria colored an aqua blue.

Changes to mitochondrial DNA spur autism-like traits in mice

Mice with a mutation in their mitochondrial DNA show altered brain activity, repetitive behaviors and reduced sociability, according to a new study.

By Laura Dattaro
17 February 2021 | 4 min read

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Trading places: What happens when neuroscience turns into machine learning, and machine learning turns into neuroscience?

Neuroscience has become increasingly concerned with prediction, and machine learning with causal explanation, with each field adopting methods from the other. I asked eight experts to weigh in on what we stand to learn from this exchange.

By Samuel Gershman
23 March 2026 | 22 min read
DNA strand

Exon-skipping approach boosts levels of key Rett syndrome protein

Deleting a small region of the MECP2 gene partially restored function in neurons derived from people with Rett-associated variants.

By Giorgia Guglielmi
20 March 2026 | 5 min read
Collage with a portrait of Caitlin Vander Weele in the foreground.

Frameshift: How Caitlin Vander Weele made science communication her business

Her favorite part of research was talking about it. So she left academia and turned that passion into a successful company.

By Katie Moisse
19 March 2026 | 6 min read