The big picture

Recent articles

Researchers ask colleagues to weigh in on important topics in the field.

Hands arrange various shapes over a color background.

Emotion research has a communication conundrum

In 2025, the words we use to describe emotions matter, but their definitions are controversial. Here, I unpack the different positions in this space and the rationales behind them—and I invite 13 experts to chime in.

By Nicole Rust
5 September 2025 | 37 min listen
Data streams into a transparent box.

Accepting “the bitter lesson” and embracing the brain’s complexity

To gain insight into complex neural data, we must move toward a data-driven regime, training large models on vast amounts of information. We asked nine experts on computational neuroscience and neural data analysis to weigh in.

By Eva Dyer, Blake Richards
26 March 2025 | 8 min read
Illustration of a funnel taking abstract shapes in at the top and spouting an organized flow of shapes out at the bottom.

To keep or not to keep: Neurophysiology’s data dilemma

An exponential growth in data size presents neuroscientists with a significant challenge: Should we be keeping all raw data or focusing on processed datasets? I asked experimentalists and theorists for their thoughts.

By Nima Dehghani
25 November 2024 | 5 min read
Illustration of an image of a landscape repeated over and over again, with some versions distorted and warped.

What makes memories last—dynamic ensembles or static synapses?

Teasing out how different subfields conceptualize central terms might help move this long-standing debate forward. I asked eight scientists to weigh in.

By Jason Shepherd
14 October 2024 | 7 min read
Collage of different images of brains and mechanical devices in the background with a suitcase in the foreground.

What are mechanisms? Unpacking the term is key to progress in neuroscience

Mechanism is a common and powerful concept, invoked in grant calls and publication guidelines. But scientists use it in different ways, making it difficult to clarify standards in the field. We asked nine scientists to weigh in.

By Dani S. Bassett, Lauren N. Ross
7 October 2024 | 5 min read
Illustration of a sparkly brain.

What, if anything, makes mood fundamentally different from memory?

To better understand mood disorders—and to develop more effective treatments—should we target the brain, the mind, the environment or all three?

By Nicole Rust
8 April 2024 | 8 min read
Illustration of a meteorologist pointing to an aerial view of clouds swirling over a brain-shaped land mass.

Is the brain uncontrollable, like the weather?

The brain may be chaotic. Does that mean our efforts to control it are doomed?

By Nicole Rust
18 December 2023 | 10 min read

Subscribe to get notified every time a new piece in “The big picture” series is published.

Explore more from The Transmitter

Illustration of two researchers attempting to use a microscope that has been twisted into a knot.

International scientific collaboration is more necessary—yet more challenging—than ever

These partnerships accelerate neuroscience by enabling researchers to share resources and expertise, as well as generate more relevant and reproducible results. But new federal funding restrictions in the United States are putting such collaborations in jeopardy.

By Lucina Q. Uddin
15 September 2025 | 6 min listen
Mother mouse with pups.

Oxytocin shapes both mouse mom and pup behavior

Distressed pups emit distinct cries for help, which depend on oxytocin neurons in their hypothalamus.

By Claudia López Lloreda
11 September 2025 | 5 min read
Research image showing cell activity in a particular region of the mouse thalamus.

Sensory gatekeeper drives seizures, autism-like behaviors in mouse model

The new work, in mice missing the autism-linked gene CNTNAP2, suggests a mechanism to help explain the overlap between epilepsy and autism.

By Diana Kwon
11 September 2025 | 5 min listen

privacy consent banner

Privacy Preference

We use cookies to provide you with the best online experience. By clicking “Accept All,” you help us understand how our site is used and enhance its performance. You can change your choice at any time. To learn more, please visit our Privacy Policy.