Synapses
Recent articles
START method assembles brain’s wiring diagram by cell type
The new technique mapped the interactions of about 50 kinds of inhibitory neurons in the mouse visual cortex in finer detail than previous approaches.
START method assembles brain’s wiring diagram by cell type
The new technique mapped the interactions of about 50 kinds of inhibitory neurons in the mouse visual cortex in finer detail than previous approaches.
Microglia’s pruning function called into question
Scientists are divided over the extent to which the cells sculpt circuits during development.
Microglia’s pruning function called into question
Scientists are divided over the extent to which the cells sculpt circuits during development.
What makes memories last—dynamic ensembles or static synapses?
Teasing out how different subfields conceptualize central terms might help move this long-standing debate forward. I asked eight scientists to weigh in.
What makes memories last—dynamic ensembles or static synapses?
Teasing out how different subfields conceptualize central terms might help move this long-standing debate forward. I asked eight scientists to weigh in.
Synaptic anomalies in autistic people support imbalance hypothesis
Increased excitatory and decreased inhibitory synapses in the prefrontal cortex of autistic people suggest broader impacts on brain function and connectivity.
Synaptic anomalies in autistic people support imbalance hypothesis
Increased excitatory and decreased inhibitory synapses in the prefrontal cortex of autistic people suggest broader impacts on brain function and connectivity.
Connectivity takes U-turn in people with rare autism-linked mutations
Patterns of brain connectivity shift during puberty in people with deletion of the 22q11.2 chromosomal region.
Connectivity takes U-turn in people with rare autism-linked mutations
Patterns of brain connectivity shift during puberty in people with deletion of the 22q11.2 chromosomal region.
CRISPR gives autism-linked genes a boost, rescues functioning
A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.
CRISPR gives autism-linked genes a boost, rescues functioning
A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Synaptic protein’s shape-shifting skills propel plasticity
SYNGAP supports learning without tapping its eponymous “GAP” enzymatic activity, according to a new study.
Synaptic protein’s shape-shifting skills propel plasticity
SYNGAP supports learning without tapping its eponymous “GAP” enzymatic activity, according to a new study.
Autism-linked perturbations converge on cell skeleton and RNA-binding proteins
The findings solidify the idea that autism-linked mutations affect brain activity by way of several key shared mechanisms.
Autism-linked perturbations converge on cell skeleton and RNA-binding proteins
The findings solidify the idea that autism-linked mutations affect brain activity by way of several key shared mechanisms.
What goes up must come down: New marker flags decreased neural activity
Phosphorylation of the metabolic enzyme pyruvate dehydrogenase inversely correlates with neural activity, offering scientists a tool to study inhibition for the first time.
What goes up must come down: New marker flags decreased neural activity
Phosphorylation of the metabolic enzyme pyruvate dehydrogenase inversely correlates with neural activity, offering scientists a tool to study inhibition for the first time.
Explore more from The Transmitter
Eli Sennesh talks about bridging predictive coding and NeuroAI
Predictive coding is an enticing theory of brain function. Building on decades of models and experimental work, Eli Sennesh proposes a biologically plausible way our brain might implement it.
Eli Sennesh talks about bridging predictive coding and NeuroAI
Predictive coding is an enticing theory of brain function. Building on decades of models and experimental work, Eli Sennesh proposes a biologically plausible way our brain might implement it.
In your New Year’s resolutions for 2025, consider public outreach
If every person in the neuroscience community committed to doing one thing, imagine the cumulative difference it would make.
In your New Year’s resolutions for 2025, consider public outreach
If every person in the neuroscience community committed to doing one thing, imagine the cumulative difference it would make.
Cerebellar SHANK3; telehealth coaching for caregivers; psychedelics
Here is a roundup of autism-related news and research spotted around the web for the last two weeks of December.
Cerebellar SHANK3; telehealth coaching for caregivers; psychedelics
Here is a roundup of autism-related news and research spotted around the web for the last two weeks of December.