Spotlight on mouse models of autism

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Spectrum Stories: Talking about autism mouse models

Scientists discuss the problems with using mice to study autism, and explain how the field might move forward.

By Jacob Brogan
21 March 2018 | 1 min read

Inside Scoop From the Autism Anchors: The role of mouse models in autism

Our autism anchors, Raphael Bernier and James Mancini, explain how mouse models can help scientists understand the causes of autism and evaluate potential treatments for the condition.

By Spectrum
21 March 2018 | 1 min read
illustration of mouse on sale in a city

‘Outmoded’ mouse models of autism may still yield new advances

Many researchers question the value of three early mouse models of autism, but the models have their staunch supporters.

By Nicholette Zeliadt
21 March 2018 | 6 min read

‘Outdated’ mouse model exposes key disruptions in autism brain

A mouse model based on exposure to an epilepsy drug offers a useful window into the brain circuits altered in autism.

By Vikaas Sohal
21 March 2018 | 6 min read

‘Syntax’ of mouse behavior may speak volumes about autism

An algorithm that decodes and quantifies mouse body language could reveal the brain circuits underlying certain autism features.

By Hannah Furfaro
21 March 2018 | 6 min read
Mouse in a lab or maze hops around sniffing here and there

Why studying autism in mice may be doomed to fail

After more than a decade of effort, scientists are questioning whether mouse models of autism can ever capture the social deficits seen in people with the condition.

By Jessica Wright
21 March 2018 | 14 min read
scientist looks through binoculars showing a boy on one side, and a mouse on the other.

Why we need a mouse version of a diagnostic test for autism

Researchers have developed behavioral measures that can accurately diagnose autism in people; these lessons can and should be applied to mice.

By Amy Esler, Nicola Grissom
21 March 2018 | 6 min read

How variability among mouse strains can aid autism research

Researchers can convert the distinct genetic backgrounds of lab mice from a problem to an advantage, exploiting the differences to advance our understanding of autism.

By Valerie Bolivar
21 March 2018 | 4 min read
Two mice in a waiting room.

What to watch for when analyzing mouse behavior

Many tests for unusual behavior in mice are prone to operator error. Here’s how to avoid common traps.

By Alla Katsnelson
21 March 2018 | 7 min read

How to improve mouse models’ usefulness for understanding autism

Integrating human-specific genetic elements into mice may provide a permissive, ‘humanized’ environment for studying autism.

By James Noonan
20 March 2018 | 5 min read

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Research image showing the number of unique SHANK3 transcripts in mice.

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