News / Spectrum

X-chromosome genes; neurobiology of infant crying; MCHAT in preemies

Here is a roundup of autism-related news and research spotted around the web for the week of 2 September.

By Jill Adams
3 September 2024 | 2 min read
comments
https://doi.org/10.53053/TMTZ3054 https://doi.org/10.53053/TMTZ3054 - opens a new tab Cite this article
  • Mice missing the autism-linked gene PTEN in specific cortical regions display disrupted temporal processing of sound across development. Neurobiology of Disease
  • The X chromosome contains many genes associated with neurodevelopmental conditions in boys and girls—in the latter, such conditions result from X-chromosome silencing. Spectrum has previously covered the role that X-chromosome genes play in brain development. Current Opinion in Neurobiology
  • Deleting the autism-linked gene CHD8 in astrocytes, but not microglia, disrupts injury-triggered reactive gliosis. Cell Reports
Research image of astrocytes and microglia in mouse brains.
Repair problems: Reactive gliosis following brain injury is disrupted in astrocytes (green stain) and microglia (red stain) in mice with the CHD8 gene knocked out in astrocytes (bottom row), unlike in control mice (top row).
  • Upregulation of two biochemical pathways known to contribute to autism alters mouse pup vocalization and synaptic connectivity, a finding that could illuminate the neurobiology involved in infant crying. Journal of Neuroscience
  • Mice missing the FMR1 gene, a model of fragile X syndrome, are hyposensitive to touch and show poor encoding of tactile stimuli in somatosensory neurons, according to a preprint. bioRxiv
  • The Modified Checklist for Autism in Toddlers (MCHAT) predicts an autism diagnosis in children born prematurely with good sensitivity and specificity, suggesting screening should not be delayed based on adjusted age. Developmental Medicine & Child Neurology
  • Linking genotypes with phenotypes in autism enables scientists to subtype the condition into classes that appear to be tied to the developmental timing of certain genes, according to a preprint. medRxiv

Sign up for the weekly Spectrum newsletter.

Stay current with the latest advancements in autism research.

Recommended reading

Research image of different types of microglia in mice.
Spectrum

Autism and anxiety insights; and more

By Jill Adams
16 September 2025 | 2 min read
Research image showing cell activity in a particular region of the mouse thalamus.
Spectrum Microphone

Sensory gatekeeper drives seizures, autism-like behaviors in mouse model

By Diana Kwon
11 September 2025 | 5 min listen
Research image of neural progenitor cells derived from people with 16p11.2 duplications and 16p11.2 deletions, which have cilia that are shorter or longer, respectively, than in controls.
Spectrum

Protein interactions important to SYNGAP1-related conditions; and more

By Jill Adams
9 September 2025 | 2 min read

Explore more from The Transmitter

Connectome

First nerve-net connectome shows how evolutionarily ancient nervous system coordinates movement

By Siddhant Pusdekar
16 September 2025 | 0 min watch
Illustration of two researchers attempting to use a microscope that has been twisted into a knot.
Funding Microphone

International scientific collaboration is more necessary—yet more challenging—than ever

By Lucina Q. Uddin
15 September 2025 | 6 min listen
Mother mouse with pups.
Oxytocin

Oxytocin shapes both mouse mom and pup behavior

By Claudia López Lloreda
11 September 2025 | 5 min read

privacy consent banner

Privacy Preference

We use cookies to provide you with the best online experience. By clicking “Accept All,” you help us understand how our site is used and enhance its performance. You can change your choice at any time. To learn more, please visit our Privacy Policy.