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SYNGAP1; executive function; synaptic density

Here is a roundup of autism-related news and research spotted around the web for the week of 14 October.

By Jill Adams

15 October 2024 | 2 min read

In mice, SYNGAP1 haploinsufficiency affects indirect neuronal pathways in the striatum more than direct pathways. Spectrum covered the state of the science of SYNGAP1 last year. Journal of Neuroscience
The timing of neurodevelopmental gene expression, derived from single-cell atlases, is a cell-specific and dynamic process. Experimental & Molecular Medicine
People with 3q29 deletion syndrome, which is linked to neurodevelopmental conditions, have global deficits in executive function that do not correlate with IQ scores. Psychological Medicine
Neuronal synapses in autistic adults have reduced density, as measured with PET scans, and lowered synaptic density correlates with a greater number of autistic features. Spectrum recently reported on the altered balance of excitatory and inhibitory synapses in autism. Molecular Psychiatry

Autistic children and teenagers with anxiety are more likely to also have depression and problems with peers than are those without anxiety. Spectrum has covered differences in the fear centers of the brain in youth with autism and anxiety. BMC Psychology
The presence and severity of autism traits may change throughout childhood. Social affect scores are most likely to improve, whereas restricted and repetitive behaviors are the most likely to stay the same. Spectrum has previously covered life trajectories in autism. Autism Research