Restoring excitation-inhibition balance in a mouse model of autism; and more

Here is a roundup of autism-related news and research spotted around the web for the week of 17 March.

By Jill Adams
18 March 2025 | 2 min read

Noise cancellation: Mice that carry autism-linked variants of the SCN2A gene show changes in neuronal activity that correlate with observed changes in sociability, according to a preprint. Mechanistically, the excitation-inhibition ratio was boosted in SCN2A-deficient neurons, creating a noisy background for social signals, the researchers found. The GABA-receptor agonist clonazepam, which can restore the balance of excitatory and inhibitory neural activity, mitigated both neuronal and behavioral changes in a manner similar to restoring SCN2A expression. bioRxiv

More autism research we spotted:

  • “Cell-type-specific roles of FOXP1 in the excitatory neuronal lineage during early neocortical murine development” Cell Reports
Research image of mouse brains showing altered migration of upper-layer neurons.
Stuck in the middle: FOXP1 loss in mouse embryos alters the migration of a subtype of upper-layer neurons (right panel) compared with development in wildtype mice (left panel).

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