- Two studies from Carla Mazefsky’s lab describe the prevalence and severity of emotional dysregulation and aggression, respectively, in autistic preschoolers. Autism Research, JAACAP Open
- General anxiety disorder does not predict social communication difficulties in school-age autistic children and adolescents. Journal of the Canadian Academy of Child and Adolescent Psychiatry
- A clinical trial participant has died after receiving a dose of Neurogene’s Rett syndrome therapy, NGN-401. Endpoints News
Emotional dysregulation; NMDA receptor variation; frank autism
Here is a roundup of autism-related news and research spotted around the web for the week of 25 November.
By
Jill Adams
26 November 2024 | 1 min read

Location, location: Human variants of the NMDA receptor occur in many areas (blue dots) on the molecular complex; those linked to neurodevelopmental conditions tend to be closer to the receptor’s pore (red dots).
- Molecular analysis of genetic variants in subunits of the NMDA receptor, some of which contribute to autism and other neurodevelopmental conditions, reveals a relationship between pathogenicity and protein structure. Human Molecular Genetics
- Initial impressions of autism traits in adolescents and young adults, used to identify frank autism, generally correlate with formal diagnosis, according to a new study, but nearly a third of autistic people in the work were misidentified as non-autistic. One of the investigators previously authored a Spectrum commentary on the concept of frank, or prototypical, autism. Molecular Autism
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Recommended reading
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Structure of striatum varies by sex in autistic children
By
Holly Barker
27 February 2025 | 4 min read
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Attention and IQ link; AUTS2-related syndrome; Glyx-13 for fragile X
By
Jill Adams
25 February 2025 | 1 min read
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Autism program chief among National Institutes of Health layoffs
By
Rachel Zamzow
21 February 2025 | 3 min read
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BCL11A-related intellectual developmental disorder; intervention dosage; gray-matter volume
By
Jill Adams
12 November 2024 | 2 min read
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Anti-seizure medications in pregnancy; TBR1 gene; microglia
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