SHANK3
Recent articles
Autism-linked perturbations converge on cell skeleton and RNA-binding proteins
The findings solidify the idea that autism-linked mutations affect brain activity by way of several key shared mechanisms.
Autism-linked perturbations converge on cell skeleton and RNA-binding proteins
The findings solidify the idea that autism-linked mutations affect brain activity by way of several key shared mechanisms.
New test taps nose pokes as a proxy for social motivation in mice
Over one hour, a particularly motivated mouse poked its nose 350 times into a hole in the test chamber in the hopes of meeting a playmate.
New test taps nose pokes as a proxy for social motivation in mice
Over one hour, a particularly motivated mouse poked its nose 350 times into a hole in the test chamber in the hopes of meeting a playmate.
Autism’s ties to the cell skeleton
Many genes related to the condition play a role in the internal scaffolding of cells, and cytoskeletal disruptions can affect neurodevelopment and behavior.
Autism’s ties to the cell skeleton
Many genes related to the condition play a role in the internal scaffolding of cells, and cytoskeletal disruptions can affect neurodevelopment and behavior.
On the periphery: Thinking ‘outside the brain’ offers new ideas about autism
Neuronal alterations outside the brain may help to explain a host of the condition’s characteristic traits, including sensory changes, gut problems and motor differences.
On the periphery: Thinking ‘outside the brain’ offers new ideas about autism
Neuronal alterations outside the brain may help to explain a host of the condition’s characteristic traits, including sensory changes, gut problems and motor differences.
Asleep in the Mouse House with Graham Diering
Memories from Diering’s life trace the rising star’s scientific path from raising lizards as a child and later exploring home brewing to heading a lab that investigates memory, sleep disturbances and early development in animals with autism-linked mutations.
Asleep in the Mouse House with Graham Diering
Memories from Diering’s life trace the rising star’s scientific path from raising lizards as a child and later exploring home brewing to heading a lab that investigates memory, sleep disturbances and early development in animals with autism-linked mutations.
One-rosette technique grows well-organized organoids
The method yields complex organoids that more closely mimic embryonic brain development than do those cultured in other ways.
One-rosette technique grows well-organized organoids
The method yields complex organoids that more closely mimic embryonic brain development than do those cultured in other ways.
Mouse models help sniff out olfactory differences in autism
A range of presentations at Neuroscience 2022 tie atypical social behavior to trouble discriminating between odors in the animals.
Mouse models help sniff out olfactory differences in autism
A range of presentations at Neuroscience 2022 tie atypical social behavior to trouble discriminating between odors in the animals.
Double SHANK knockout highlights brain circuit’s social role
Mice missing the autism-linked SHANK2 and SHANK3 genes in their retrosplenial cortex have trouble distinguishing between novel and familiar mice.
Double SHANK knockout highlights brain circuit’s social role
Mice missing the autism-linked SHANK2 and SHANK3 genes in their retrosplenial cortex have trouble distinguishing between novel and familiar mice.
Lost sleep sparks lasting social problems in SHANK3 mice
Sleep disruption early in life has long-lasting consequences for mice missing a copy of the autism-linked gene SHANK3.
Lost sleep sparks lasting social problems in SHANK3 mice
Sleep disruption early in life has long-lasting consequences for mice missing a copy of the autism-linked gene SHANK3.
Sleepy mice with autism-linked mutation struggle to fall asleep
Mice with a mutated copy of SHANK3 fail to establish normal sleep patterns during development.
Sleepy mice with autism-linked mutation struggle to fall asleep
Mice with a mutated copy of SHANK3 fail to establish normal sleep patterns during development.
Explore more from The Transmitter
Why emotion research is stuck—and how to move it forward
Studying how organisms infer indirect threats and understand changing contexts can establish a common framework that bridges species and levels of analysis.
Why emotion research is stuck—and how to move it forward
Studying how organisms infer indirect threats and understand changing contexts can establish a common framework that bridges species and levels of analysis.
After NINDS director ouster, 40 neuroscience organizations press U.S. Congress for oversight over hiring process
A letter signed by the groups asks Congress to ensure that scientific expertise remains a priority in the search for a new director of the National Institute of Neurological Disorders and Stroke.
After NINDS director ouster, 40 neuroscience organizations press U.S. Congress for oversight over hiring process
A letter signed by the groups asks Congress to ensure that scientific expertise remains a priority in the search for a new director of the National Institute of Neurological Disorders and Stroke.
BRAIN Initiative researchers ‘dream big’ amid shifts in leadership, funding
But whether the initiative’s road map for the next decade is feasible remains an open question.
BRAIN Initiative researchers ‘dream big’ amid shifts in leadership, funding
But whether the initiative’s road map for the next decade is feasible remains an open question.