SCN2A
Recent articles
Boosting SCN2A expression reduces seizures in mice
A modified form of CRISPR amps up expression of the gene—a strategy that could apply to other gene variations linked to autism.
Boosting SCN2A expression reduces seizures in mice
A modified form of CRISPR amps up expression of the gene—a strategy that could apply to other gene variations linked to autism.
Widely used calcium imaging protocol can lead to spurious results, new paper cautions
The technique, which measures calcium currents as a proxy for neuronal firing, sometimes reports unusual and potentially misleading waves of activity in the hippocampus.
Widely used calcium imaging protocol can lead to spurious results, new paper cautions
The technique, which measures calcium currents as a proxy for neuronal firing, sometimes reports unusual and potentially misleading waves of activity in the hippocampus.
CRISPR gives autism-linked genes a boost, rescues functioning
A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.
CRISPR gives autism-linked genes a boost, rescues functioning
A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Mutation in top autism-linked gene may alter eye reflex
The discovery could help clinicians diagnose children who carry mutations in the gene, called SCN2A, and gauge their responses to potential therapies.
Mutation in top autism-linked gene may alter eye reflex
The discovery could help clinicians diagnose children who carry mutations in the gene, called SCN2A, and gauge their responses to potential therapies.
Top autism-linked genes join forces to shape synaptic plasticity
The protein products of ANK2 and SCN2A interact to regulate dendritic excitability.
Top autism-linked genes join forces to shape synaptic plasticity
The protein products of ANK2 and SCN2A interact to regulate dendritic excitability.
Autism research hits the road
Some scientists are thinking creatively about how to collect data in flexible environments and meet communities where they’re at.
Autism research hits the road
Some scientists are thinking creatively about how to collect data in flexible environments and meet communities where they’re at.
Latest ‘prime-editing’ tools tackle delivery, safety issues
The gene-editing advances make it easier to target specific tissues in mice and detect off-target effects.
Latest ‘prime-editing’ tools tackle delivery, safety issues
The gene-editing advances make it easier to target specific tissues in mice and detect off-target effects.
New evidence hints at mechanisms for ‘fever effect’ in autism
The temporary easing of traits that a minority of autistic children are reported to show during or after a fever may stem from a rise in body temperature.
New evidence hints at mechanisms for ‘fever effect’ in autism
The temporary easing of traits that a minority of autistic children are reported to show during or after a fever may stem from a rise in body temperature.
Dispatches from SfN 2021: Mitochondria, Rett therapy and oxytocin
These short reports from Spectrum journalists highlight some of the autism-related findings that caught our attention at the meeting this past week.
Dispatches from SfN 2021: Mitochondria, Rett therapy and oxytocin
These short reports from Spectrum journalists highlight some of the autism-related findings that caught our attention at the meeting this past week.
Explore more from The Transmitter
Head direction cells stably orient mice to outside world
The cells’ representations show little drift over time—unlike those of other navigation system neurons—and may provide a “rigid backbone” for more flexible sensory and cognitive responses.
Head direction cells stably orient mice to outside world
The cells’ representations show little drift over time—unlike those of other navigation system neurons—and may provide a “rigid backbone” for more flexible sensory and cognitive responses.
Juan Gallego discusses how manifolds are transforming our understanding of the coordination of neuronal population activity
A wealth of evidence supports the view that neural manifolds are real and useful, Gallego says, even if they may not completely solve the age-old mind-body problem.
Juan Gallego discusses how manifolds are transforming our understanding of the coordination of neuronal population activity
A wealth of evidence supports the view that neural manifolds are real and useful, Gallego says, even if they may not completely solve the age-old mind-body problem.
Astrocytes in mouse amygdala encode emotional state
The glial cells’ activity reliably tracks with freezing, hesitancy and other behaviors reminiscent of anxiety.
Astrocytes in mouse amygdala encode emotional state
The glial cells’ activity reliably tracks with freezing, hesitancy and other behaviors reminiscent of anxiety.