Purkinje cells

Recent articles

A slice of a cerebellum.

Mutation in top autism-linked gene may alter eye reflex

The discovery could help clinicians diagnose children who carry mutations in the gene, called SCN2A, and gauge their responses to potential therapies.

By Charles Q. Choi
26 February 2024 | 5 min read
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: Brain aging, oxytocin pathways, biomarker back-up

Null and replicated results in this month’s newsletter tackle aging, a purported pathway for oxytocin’s effects on autistic people, and a possible autism biomarker.

By Emily Harris
15 September 2022 | 5 min read

Mouse study links dopamine in cerebellum to social behavior

The signaling molecule’s social role in the ‘little brain’ involves Purkinje neurons in the Crus I and Crus II regions, a new study reveals.

By Sarah DeWeerdt
6 July 2022 | 5 min read

Mice missing key clock gene show autism-like traits

A new study is the first to link social, repetitive and motor behaviors to mutations in BMAL1, which regulates the body’s circadian rhythms.

By Laura Dattaro
28 April 2022 | 5 min read

Autism model mice develop typical social and motor behaviors after drug treatment

The drug suppresses an overactive signaling pathway implicated in tuberous sclerosis complex.

By Laura Dattaro
9 March 2022 | 5 min read
lab mice

Mice with autism-related mutations show brain signaling imbalance

Mutations in POGZ, a gene strongly linked to autism, lead to a signaling imbalance in multiple brain regions in mice, according to two new studies.

By Angie Voyles Askham
4 January 2021 | 7 min read
Illustration showing the human brain with neurons made out of flower shapes and the cerebellum highlighted in gold and yellow.

Brain’s motor hub plays unsung role in social skills, cognition

Long known as the director of movement, the cerebellum may also coordinate social and cognitive abilities, including those central to autism.

By Sarah DeWeerdt
9 March 2020 | 7 min read

Fake autism claim; knocking out anesthesia; haunting milestone and more

Despite social media rumors, a British children’s television show does not cause autism; childhood anesthesia is not tied to autism risk; and an adult on the spectrum reaches a haunting milestone

By Emily Willingham
23 February 2018 | 5 min read
four brains with the RCrusl section highlighted

Study of cerebellum’s role in autism homes in on ‘social’ region

New evidence from both people and mice points to a part of the cerebellum that helps process social information as being critical in autism.

By Hannah Furfaro
18 December 2017 | 5 min read
Spectrum from The Transmitter.

Timed cues create mini-cerebellum in culture

Researchers can coax human stem cells to grow into layered structures that mimic the brain’s center for motor control, the cerebellum.

By Maris Fessenden
25 February 2015 | 3 min read

Explore more from The Transmitter

Illustration of two researchers attempting to use a microscope that has been twisted into a knot.

International scientific collaboration is more necessary—yet more challenging—than ever

These partnerships accelerate neuroscience by enabling researchers to share resources and expertise, as well as generate more relevant and reproducible results. But new federal funding restrictions in the United States are putting such collaborations in jeopardy.

By Lucina Q. Uddin
15 September 2025 | 6 min listen
Mother mouse with pups.

Oxytocin shapes both mouse mom and pup behavior

Distressed pups emit distinct cries for help, which depend on oxytocin neurons in their hypothalamus.

By Claudia López Lloreda
11 September 2025 | 5 min read
Research image showing cell activity in a particular region of the mouse thalamus.

Sensory gatekeeper drives seizures, autism-like behaviors in mouse model

The new work, in mice missing the autism-linked gene CNTNAP2, suggests a mechanism to help explain the overlap between epilepsy and autism.

By Diana Kwon
11 September 2025 | 5 min listen

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