Profound autism

Recent articles

A boy manipulates blocks at a table while sitting across from a woman taking notes.

Prevalence of profound autism declines with new definition

The updated, more precise definition used in a CDC study includes adaptive scores.

By Brianna Abbott
22 October 2026 | 5 min read
Research image of autism-linked gene PTEN changes in neurons.

A consensus on the definition of profound autism, and more

Here is a roundup of autism-related news and research spotted around the web for the week of 5 July.

By Sarah Thau
7 July 2026 | 2 min read
Conference attendees.

Reporter’s notebook: Highlights from INSAR 2026

At the 25th annual meeting of the International Society for Autism Research, scientists, clinicians and self-advocates gathered to discuss topics such as autism genetics and the gap between clinical trials and real-world benefits.

By Diana Kwon
30 April 2026 | 6 min read
A clinician holds a clipboard while someone else sits on a couch.

Expediting clinical trials for profound autism: Q&A with Matthew State

Aligning Research to Impact Autism, a new initiative funded by the Sergey Brin Family Foundation, wants to bring basic science discoveries to the clinic faster.

By Lauren Schenkman
24 April 2025 | 8 min read
Black-and-white research image of brain organoids.

Brain organoid size matches intensity of social problems in autistic people

Overgrown organoids could point to mechanisms underlying profound autism.

By Holly Barker
18 July 2024 | 5 min read
Portrait of Matthew Siegel sitting on a staircase.

Pinning down ‘profound autism’ for reliable research: Q&A with Matthew Siegel

A clear and actionable definition for the term could enhance research and improve care, Matthew Siegel says.

By Katie Moisse
13 June 2024 | 7 min read

Building bridges: Collaboration across the autism community

An autistic person and the mother of an autistic child explore partnership in the autism community.

By Samantha Easter, Amy S.F. Lutz
24 October 2023 | 10 min read
Photograph of a woman in a dim room looking out her window.

Weaponized heterogeneity only harms the most vulnerable autistic people

Focusing on aspects of autistic experience that we all share may lead more quickly to our shared goal of improved outcomes for all autistic people.

By Mary Doherty
17 April 2023 | 8 min read
Lone figure treads a central path that splits into two, surrounded on both sides by an uncertain, shifting landscape in murky colors.

It’s time to embrace ‘profound autism’

My experience at the Autism-Europe International Congress — and as a parent of a child with profound autism — makes me more convinced than ever that we need to bifurcate the diagnosis of ‘autism spectrum disorder’ and add a new diagnosis of ‘profound autism’ to better serve this vulnerable population.

By Alison Singer
27 October 2022 | 8 min read
An abstract "funding mechanism" featuring dollar bills alongside tubes, beakers and wires

New program offers $35K grants to study ‘profound autism’

People who have ‘profound autism’ — those with severe intellectual disability, limited communication abilities or both — tend to be excluded from research. The Autism Science Foundation seeks to change that.

By Peter Hess
18 July 2022 | 5 min read

Explore more from The Transmitter

Illustration of a bridge shaped like minds.

Commentary: Citation graphs may underestimate neuroscience’s influence on AI

An alternative, albeit less quantitative, way to trace this history is through the people who carried ideas between the fields.

By Anthony Zador
26 October 2026 | 5 min read
Illustration of a person, shown from the torso down, walking over a bridge shaped like minds.

Commentary: The rising absolute number of neuro-inspired AI papers represents a substantial footprint

Many of the design choices present in the current generation of artificial-intelligence tools parallel purported properties of the brain.

By Kim Stachenfeld
26 October 2026 | 2 min read
Illustration of a person walking over a bridge shaped like minds.

Examining the bridge between neuroscience and AI

A citation analysis reveals that the connection between the two fields is real and gaining momentum. But it’s also narrow and tool-heavy; we need to find ways to widen it.

By Renato Duarte
26 October 2026 | 12 min read