Neuromodulators

Recent articles

Archery target.

What should the field prioritize over the next 10 years?

Respondents pointed to a range of challenges in basic neuroscience—such as understanding naturalistic behaviors, intelligence and embodied cognition—and called for more circuit-level research, more precise brain recordings and more work in alternative models. Just as many pushed for a translational pivot.

By The Transmitter
15 November 2025 | 11 min read
Research image of serotonin and dopamine neurons manipulated simultaneously in mice.

Dopamine ‘gas pedal’ and serotonin ‘brake’ team up to accelerate learning

Mice learn fastest and most reliably when they experience an increase in dopamine paired with an inhibition of serotonin in their nucleus accumbens, a new study shows, helping to resolve long-standing questions about the neuromodulators’ relationship.

By Angie Voyles Askham
12 February 2025 | 5 min read

Explore more from The Transmitter

Nerve fibers from the human graft in mouse brain.

Human brain organoids flourish in emptied mouse cortex

The chimeric mice could help untangle the biology of human brain development or conditions such as autism.

By Brianna Abbott
16 September 2026 | 6 min read

What if Hegel were a neuroscientist?

Andrea Gambarotto shares what Hegel and enactivism have in common: an agency-first approach to understanding minds and brains.

By Paul Middlebrooks
16 September 2026 | 1 min read
Illustration of genetic associations.

This paper changed my life: Transformative work in addiction neuroscience

A 2011 Nature study found that loss of a nicotinic receptor subunit leads to increased nicotine intake in mice. The work set the standard for how to functionally validate genetic association study findings in neuroscience.

By Jibran Khokhar
16 September 2026 | 6 min read