Neurodevelopment
Recent articles
The genome offers a recipe, not a blueprint, for the brain
During brain development, genes set the rules and turn the knobs; self-organization does much of the rest.
The genome offers a recipe, not a blueprint, for the brain
During brain development, genes set the rules and turn the knobs; self-organization does much of the rest.
Human brain organoids come of age—but still have room to grow
The U.S. government has touted organoids as an alternative to animals for studying the brain. The model has improved since its debut in 2013, but scientists are still working to overcome key limitations: immaturity, consistency and the lack of vascularization.
Human brain organoids come of age—but still have room to grow
The U.S. government has touted organoids as an alternative to animals for studying the brain. The model has improved since its debut in 2013, but scientists are still working to overcome key limitations: immaturity, consistency and the lack of vascularization.
University probe leads to retraction of four neural tube studies
The University of Maryland conducted an internal investigation that identified image duplications and other data integrity issues in the studies, according to the retraction notices.
University probe leads to retraction of four neural tube studies
The University of Maryland conducted an internal investigation that identified image duplications and other data integrity issues in the studies, according to the retraction notices.
Hasty stem cells highlight potential limitation with cortical organoids
The models recapitulate many key developmental processes, but some radial glial cells in mouse organoids make neurons earlier than they should.
Hasty stem cells highlight potential limitation with cortical organoids
The models recapitulate many key developmental processes, but some radial glial cells in mouse organoids make neurons earlier than they should.
Human brain organoids flourish in emptied mouse cortex
The chimeric mice could help untangle the biology of human brain development or conditions such as autism.
Human brain organoids flourish in emptied mouse cortex
The chimeric mice could help untangle the biology of human brain development or conditions such as autism.
Infant memories: Lost but not gone?
Infantile amnesia is not simply a story about forgetting the past. It is an opportunity to understand how memory itself is built.
Infant memories: Lost but not gone?
Infantile amnesia is not simply a story about forgetting the past. It is an opportunity to understand how memory itself is built.
Autism-linked variants rewire protein networks
The myriad proteins tied to autism cluster in previously unrecognized ways that can be disrupted by specific variants in the proteins.
Autism-linked variants rewire protein networks
The myriad proteins tied to autism cluster in previously unrecognized ways that can be disrupted by specific variants in the proteins.
Nuclear location helps control gene activity during brain development
A study of developing human brain tissue suggests that genes switch on more strongly when they move from the nucleus’s edge toward structures that contain proteins involved in making and processing RNA.
Nuclear location helps control gene activity during brain development
A study of developing human brain tissue suggests that genes switch on more strongly when they move from the nucleus’s edge toward structures that contain proteins involved in making and processing RNA.
Five-year-old human brain organoids aged on schedule
The cultured spheres typically mimic only prenatal development, but the five-year-old ones grown in Paola Arlotta’s lab acquired postnatal features.
Five-year-old human brain organoids aged on schedule
The cultured spheres typically mimic only prenatal development, but the five-year-old ones grown in Paola Arlotta’s lab acquired postnatal features.
Loss of interneuron plasticity may be shared hallmark of neurodevelopmental conditions
Restoring an experience-dependent interneuron plasticity gene in adulthood improves memory and cuts seizures in CNTNAP2 knockout mice, a new study shows.
Loss of interneuron plasticity may be shared hallmark of neurodevelopmental conditions
Restoring an experience-dependent interneuron plasticity gene in adulthood improves memory and cuts seizures in CNTNAP2 knockout mice, a new study shows.
Explore more from The Transmitter
Autism research involving monkeys contends with uphill battle
Macaques and marmosets recapitulate the condition’s core traits better than mice can, but funding uncertainty and challenges at primate centers in the United States could make this work difficult to continue.
Autism research involving monkeys contends with uphill battle
Macaques and marmosets recapitulate the condition’s core traits better than mice can, but funding uncertainty and challenges at primate centers in the United States could make this work difficult to continue.
When is self-organization a mechanism in brain development?
Retinal waves offer a powerful example of a self-organizing system that can build structure without external guidance. The field would do well to embrace such phenomena more broadly as a type of mechanistic explanation.
When is self-organization a mechanism in brain development?
Retinal waves offer a powerful example of a self-organizing system that can build structure without external guidance. The field would do well to embrace such phenomena more broadly as a type of mechanistic explanation.
Fly taste connectome traces paths from sensation to action
The map—the first of its kind for an animal more complex than Caenorhabditis elegans—gives neuroscientists a trove of testable hypotheses about how neuronal circuits guide feeding behaviors.
Fly taste connectome traces paths from sensation to action
The map—the first of its kind for an animal more complex than Caenorhabditis elegans—gives neuroscientists a trove of testable hypotheses about how neuronal circuits guide feeding behaviors.