Neurodegenerative disorders

Recent articles

Illustration of complex, intersecting biological structures.

Everything, everywhere, all at once: Inside the chaos of Alzheimer’s disease

To truly understand Alzheimer’s disease, we may need to take a systems approach, in which inflammation, vascular injury, impaired glucose metabolism and other factors interact in complex ways.

By Michael A. Yassa
16 June 2025 | 7 min read

The brain’s quiet conductor: How hidden cells fine-tune arousal

New research published today suggests that the pericoeruleus acts as a kind of micromanager of arousal, selectively inhibiting different subgroups of locus coeruleus neurons depending on the behavioral context.

By Mac Shine
7 May 2025 | 59 min watch
Research image of human cortical neurons xenotransplanted into a mouse brain for months.

In vivo veritas: Xenotransplantation can help us study the development and function of human neurons in a living brain

Transplanted cells offer insight into human-specific properties, such as a lengthy cortical development and sensitivity to neurodevelopmental and neurodegenerative disease.

By Pierre Vanderhaeghen
7 April 2025 | 9 min listen
Six different neurons.

Early trajectory of Alzheimer’s tracked in single-cell brain atlases

Inflammation in glia and the loss of certain inhibitory cells may kick off a disease cascade decades before diagnosis.

By Angie Voyles Askham
23 October 2024 | 8 min read
A collage illustration of a woman’s face fragmented by a mosaic of X chromosomes, lines and shapes.

Brains, biases and amyloid beta: Why the female brain deserves a closer look in Alzheimer’s research

New results suggest the disease progresses differently in women, but we need more basic science to unpack the mechanisms involved.

By Rachel Buckley
22 October 2024 | 8 min listen
Illustrated portrait of Tim Ryan.

Timothy Ryan on his pivotal switch from studying particle physics to decoding synaptic transmission

Dissuaded from pursuing theoretical physics and deterred by the “long feedback loop” in experimental physics, the National Academy of Sciences member took inspiration from “polymath” Watt Webb and “visionary” Stephen Smith—and learned to work “completely outside his comfort zone.”

By Brady Huggett
1 October 2024 | 70 min listen
Illustration of a group of books floating against a light blue and yellow background.

Six new neuroscience books for fall—plus five titles you may have missed

We highlight the most anticipated neuroscience books for the remainder of 2024 and recap notable releases since last December.

By Francisco J. Rivera Rosario
26 August 2024 | 6 min read
Research image of tau proteins in the brains of people with Alzheimer’s disease.

Supersized version of Alzheimer’s protein avoids clumping in brain

“Big tau” may explain why some brain regions, such as the cerebellum and brainstem, are largely spared from neurodegeneration, even though tau is expressed throughout the nervous system.

By Charles Q. Choi
16 August 2024 | 6 min read
Photograph of Carol Jennings.

Carol Jennings, whose family’s genetics informed amyloid cascade hypothesis, dies at 70

Her advocacy work aided the discovery of a rare inherited form of early-onset Alzheimer’s disease and helped connect affected people with researchers.

By Elissa Welle
30 April 2024 | 4 min listen

Explore more from The Transmitter

ABCD Study omits gender-identity data from latest release

The removal counteracts the goals of the longitudinal study by “pretending that some aspects of adolescent brain development don’t exist,” says sex differences researcher Nicola Grissom.

By Calli McMurray
11 July 2025 | 4 min read
Leafcutter ants carrying leaves.

Neuropeptides reprogram social roles in leafcutter ants

The mechanisms that control the labor roles of ants may also be conserved in naked mole rats, a new study shows.

By Shaena Montanari
11 July 2025 | 7 min listen
Illustration of overlapping, multi-colored human head silhouettes.

Perspectives from the field: Opinions in autism research

This collection of Spectrum articles from the past 12 months highlights expert perspectives on autism’s heritability and its link to biological sex, the value of transdiagnostic frameworks, and the field’s future, among other topics.

By Daisy Yuhas
10 July 2025 | 3 min read