Neurodegeneration
Recent articles
Allen Institute sets sights on treatments for five brain diseases
The Brain Health Accelerator program aims to harness single-cell transcriptomics and cell-type-specific genetic tools to develop treatments for Alzheimer’s, Huntington’s and Parkinson’s diseases, Lewy body dementia and ALS.
Allen Institute sets sights on treatments for five brain diseases
The Brain Health Accelerator program aims to harness single-cell transcriptomics and cell-type-specific genetic tools to develop treatments for Alzheimer’s, Huntington’s and Parkinson’s diseases, Lewy body dementia and ALS.
Gene activity in human cortex shows striking sex differences
The results mark a “dramatic shift” in how neuroscientists think about sex differences, and they may help explain sex biases in certain neurodegenerative and neurodevelopmental conditions.
Gene activity in human cortex shows striking sex differences
The results mark a “dramatic shift” in how neuroscientists think about sex differences, and they may help explain sex biases in certain neurodegenerative and neurodevelopmental conditions.
Aging neurons outsource garbage disposal, clog microglia
Degradation-resistant proteins pass from neurons to glial cells in a process that may spread protein clumps around the brain, according to a study in mice.
Aging neurons outsource garbage disposal, clog microglia
Degradation-resistant proteins pass from neurons to glial cells in a process that may spread protein clumps around the brain, according to a study in mice.
Bringing African ancestry into cellular neuroscience
Two independent teams in Africa are developing stem cell lines and organoids from local populations to explore neurodevelopmental and neurodegenerative conditions.
Bringing African ancestry into cellular neuroscience
Two independent teams in Africa are developing stem cell lines and organoids from local populations to explore neurodevelopmental and neurodegenerative conditions.
How goats can model neurodegeneration
Since debunking an urban legend that headbutting animals don’t damage their brain, Nicole Ackermans has been investigating how the behavior correlates with neurodegeneration.
How goats can model neurodegeneration
Since debunking an urban legend that headbutting animals don’t damage their brain, Nicole Ackermans has been investigating how the behavior correlates with neurodegeneration.
What are the most-cited neuroscience papers from the past 30 years?
Highly cited papers reflect the surge in artificial-intelligence research in the field and other technical advances, plus prizewinning work on analgesics, the fusiform face area and ion channels.
What are the most-cited neuroscience papers from the past 30 years?
Highly cited papers reflect the surge in artificial-intelligence research in the field and other technical advances, plus prizewinning work on analgesics, the fusiform face area and ion channels.
New questions around motor neurons and plasticity
A researcher’s theory hangs muscle degeneration on a broken neural circuit.
New questions around motor neurons and plasticity
A researcher’s theory hangs muscle degeneration on a broken neural circuit.
Paper by memory institute director garners expression of concern over image integrity
The notice, posted last week in Nature, follows a recent string of corrections to at least three other articles by Li-Huei Tsai’s lab.
Paper by memory institute director garners expression of concern over image integrity
The notice, posted last week in Nature, follows a recent string of corrections to at least three other articles by Li-Huei Tsai’s lab.
How to teach this paper: ‘Neurotoxic reactive astrocytes are induced by activated microglia,’ by Liddelow et al. (2017)
Shane Liddelow and his collaborators identified the factors that transform astrocytes from their helpful to harmful form. Their work is a great choice if you want to teach students about glial cell types, cell culture, gene expression or protein measurement.
How to teach this paper: ‘Neurotoxic reactive astrocytes are induced by activated microglia,’ by Liddelow et al. (2017)
Shane Liddelow and his collaborators identified the factors that transform astrocytes from their helpful to harmful form. Their work is a great choice if you want to teach students about glial cell types, cell culture, gene expression or protein measurement.
Single-cell genomics technologies and cell atlases have ushered in a new era of human neurobiology
Single-cell approaches are already shedding light on the human brain, identifying cell types that are most vulnerable in the early stages of Alzheimer’s disease, for example.
Single-cell genomics technologies and cell atlases have ushered in a new era of human neurobiology
Single-cell approaches are already shedding light on the human brain, identifying cell types that are most vulnerable in the early stages of Alzheimer’s disease, for example.
Explore more from The Transmitter
Is our intelligence rooted in how living organisms are organized?
Kathryn Nave explains how a concept called constraint closure may be fundamental to understanding brains, minds and cognition.
Is our intelligence rooted in how living organisms are organized?
Kathryn Nave explains how a concept called constraint closure may be fundamental to understanding brains, minds and cognition.
Making an impact through academic administration
As executive director of research at Harvard Medical School’s Department of Neurobiology, Soha Ashrafi supports more than 300 scientists, students and staff members.
Making an impact through academic administration
As executive director of research at Harvard Medical School’s Department of Neurobiology, Soha Ashrafi supports more than 300 scientists, students and staff members.
This paper changed my life: Embracing an early model for naturalistic neuroscience
A 1992 PNAS paper showed how birdsong upregulates the expression of an immediate early gene in bird forebrains. The work revealed to Ribeiro the importance of studying molecular responses in naturalistic contexts.
This paper changed my life: Embracing an early model for naturalistic neuroscience
A 1992 PNAS paper showed how birdsong upregulates the expression of an immediate early gene in bird forebrains. The work revealed to Ribeiro the importance of studying molecular responses in naturalistic contexts.