Monkeys for autism research

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The treasures of monkey island

On Cayo Santiago island, scientists track the alliances and power struggles of a colony of feral monkeys — collecting data to generate new insights into the social challenges that people with autism face.

By Brendan Borrell
22 June 2016 | 23 min read

Genetically modified monkeys show autism-like behaviors

Monkeys with multiple copies of a gene called MeCP2 show behaviors reminiscent of autism, but some experts question the model’s value.

By Nicholette Zeliadt
27 January 2016 | 6 min read

Questions for Cory Miller: Monkeying around with marmosets

Small social monkeys called marmosets are well suited for studies on social behaviors and autism.

By Nicholette Zeliadt
10 May 2016 | 5 min read

From the archives

Questions for Karen Parker: Probing monkey social behavior

Like people, monkeys vary widely in their social abilities. Behavioral neuroscientist Karen Parker explains how studying social behavior in monkeys can advance how we understand and treat autism.

By Nicholette Zeliadt
4 November 2014 | 6 min read

Monkey mother’s immune response changes her infant’s brain

Monkeys whose mothers are infected with a mock virus while pregnant show abnormal branching of certain brain cells. The findings may help explain why infection during a woman’s pregnancy ups the risk of autism in her children.

By Charles Q. Choi
27 April 2015 | 3 min read

New tool offers way to ‘light up’ cells in monkey brain

A new technique can stimulate and record activity across broad swaths of the monkey brain.

By Ann Griswold
16 March 2016 | 3 min read

Atlas charts gene activity in developing monkey brains

Researchers have for the first time mapped gene expression in the rhesus macaque brain from birth through adulthood. The atlas illuminates the expression patterns of genes likely to be important in autism.

By Kate Yandell
10 June 2015 | 3 min read

Marmosets that miss social cues may mimic autism

Marmosets exposed to an epilepsy drug in the womb do not recognize reciprocity — the social give-and-take that is a challenge for some people with autism — suggests a new study. The findings add to mounting evidence that these tiny monkeys offer clues about autism.

By Kate Yandell
29 July 2015 | 3 min read

Video technique measures monkeys’ social interest

Male rhesus macaques show more interest in videos with social content, such as another monkey displaying aggression, than in videos of landscapes or other animals, according to a study published 26 October in PLoS One.

By Jessica Wright
11 January 2012 | 3 min read

Engineered monkeys carry autism-linked mutations

Researchers have created the first genetic monkey model of autism, they reported 6 March in Cell Stem Cell. The female monkey has a mutated version of the MeCP2 gene that causes Rett syndrome.

By Jessica Wright
9 April 2014 | 2 min read

Neurons move early, mature late in developing monkey brain

Researchers have mapped the migration patterns of neurons in the developing monkey brain and pinpointed when they establish their identities.

By Katie Moisse
19 October 2015 | 3 min read

Social hormone may lead to solo outlook in monkey brains

Contrary to its reputation, oxytocin may make monkeys less interested in others’ actions and more focused on their own.

By Jessica Wright
19 October 2015 | 4 min read

Monkey models march into autism research arena

Overcoming profound technical challenges, researchers may be well on their way to making a troop of monkey models for studying autism and related conditions

By Jessica Wright
21 October 2015 | 4 min read

On monkey island, some animals carry autism-linked mutation

Roughly one-sixth of the monkeys on an island off the coast of Puerto Rico may carry a variant in SHANK3, a top autism gene candidate.

By Jessica Wright
20 October 2015 | 4 min read

Researchers flag targets of autism-linked antibodies

Two studies published 9 July bolster the hypothesis that immune molecules in a pregnant woman’s bloodstream may sometimes cause autism in her child.

By Sarah DeWeerdt
25 July 2013 | 7 min read

Mother’s immune response triggers odd behavior in monkeys

Triggering immune defenses in pregnant monkeys can lead to repetitive behaviors and social problems in their babies, according to a study published 4 September in Biological Psychiatry.

By Jessa Netting
7 October 2013 | 4 min read

Video: What monkeys can teach us about autism

Earl Miller tells SFARI.org how monkeys inspired his theory for the cognitive deficits in autism.

By Jessica Wright
12 November 2011 | 2 min read

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Assembloids illuminate circuit-level changes linked to autism, neurodevelopment

These complex combinations of organoids afford a closer look at how gene alterations affect certain brain networks.

By Sarah DeWeerdt
19 December 2024 | 0 min watch
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Rajesh Rao reflects on predictive brains, neural interfaces and the future of human intelligence

Twenty-five years ago, Rajesh Rao proposed a seminal theory of how brains could implement predictive coding for perception. His modern version zeroes in on actions.

By Paul Middlebrooks
18 December 2024 | 97 min listen