Microscopy

Recent articles

New tissue-clearing techniques let microscopes peer deeper into living brains

Washing mouse brain tissue with a blood protein or complex sugar can illuminate cells 550 micrometers into the cortex without compromising its normal physiology.

By Calli McMurray
18 October 2024 | 0 min watch

Octopus arm anatomy, molecular makeup revealed in new maps

The datasets provide “a very nice reference” for future functional studies.

By Calli McMurray
25 September 2024 | 1 min watch
A dense reconstruction of layer 2/3 neurons of the mouse visual cortex containing 394 neurons and 3.2 million synapses.

To develop better nervous-system visualizations, we need to think BIG

With a full mouse connectome on the horizon, neuroscience needs to overcome its legacy of minimalism and embrace the contemporary challenge of representing whole-nervous-system connectivity.

By Tyler Sloan
8 July 2024 | 8 min read
Image of neural activity in a mouse as seen through the Miniscope.

Designing an open-source microscope

Funding for the development of open-source tools is on the rise, but support for their maintenance and dissemination, both crucial for their meaningful uptake, remains a major challenge.

By Daniel Aharoni
17 June 2024 | 6 min read

Getting musical to spot patterns in whole-brain imaging data: Q&A with Elizabeth Hillman

The new technique takes advantage of humans’ “extraordinary” sensory processing abilities, Hillman says.

By Calli McMurray
21 February 2024 | 0 min watch

Robotic headgear records brain activity in moving mice

The tool could help researchers study the neurobiology of natural behaviors, scientists say.

By Holly Barker
3 August 2023 | 5 min read

Explore more from The Transmitter

Research image of cells lacking microexon 4.

Protein aggregates gum up ‘master regulator’ of autism-linked genes

The regulator, CPEB4, typically controls protein production for hundreds of autism-linked genes, but an alternative version of it found in autistic people forms irreversible clumps and malfunctions.

By Giorgia Guglielmi
23 January 2025 | 4 min read
Violet-stained neurons in a serial transverse section from an embryonic spiny dogfish, a bottom-dwelling shark.

Digitization of ‘breathtaking’ neuroanatomy slide collection offers untapped research gold mine

Thousands of histological sections of vertebrate brains—including from spiny dogfish, turtles and more—are newly available online.

By Shaena Montanari
22 January 2025 | 3 min read
Research image of brain organoids with astroglia formation represented in green.

Personalized medicine; astroglia organoids; fast track for fragile X drug

Here is a roundup of autism-related news and research spotted around the web for the week of 20 January.

By Jill Adams
21 January 2025 | 2 min read