Methods

Recent articles

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Spectrum 2024: Year in review

We round up our most notable autism stories of the past 12 months.

By Daisy Yuhas
23 December 2024 | 2 min read
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The non-model organism “renaissance” has arrived

Meet 10 neuroscientists bringing model diversity back with the funky animals they study.

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Solving intelligence requires new research and funding models

Our research ecosystem isn't built to deliver the breakthroughs needed to understand intelligence at scale. We need a dedicated research institution to take up the task.

By David A. Markowitz
13 December 2024 | 6 min read
Illustration of a person holding a box that is emitting laser-like beams and projecting a large curved black surface.

Imagining the ultimate systems neuroscience paper

A growing body of papers on systems neuroscience and on giant simulations of neural circuits involves data beyond the point that anyone can reasonably understand end to end. Looking ahead, “paper-bots” could solve that problem.

By Mark Humphries
2 December 2024 | 8 min read
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To keep or not to keep: Neurophysiology’s data dilemma

An exponential growth in data size presents neuroscientists with a significant challenge: Should we be keeping all raw data or focusing on processed datasets? I asked experimentalists and theorists for their thoughts.

By Nima Dehghani
25 November 2024 | 5 min read

Expanding set of viral tools targets almost any brain cell type

Harmless viruses that encase short noncoding DNA elements called enhancers enable cell-type-specific gene delivery across the central nervous system in rodents and primates.

By Holly Barker
19 November 2024 | 2 min watch
Illustration of a thermostat set to 22 point 5 degrees celsius, with a silhouette of a mouse adjusting its dial.

Mouse housing temperatures can cook experimental outcomes

Neuroscientists need to take note of how thermoregulatory processes influence the brain and behavior—for the sake of reproducibility and animal welfare.

By Caitlin James, Elizabeth Repasky, Sandra Sexton
5 November 2024 | 5 min read
Research image of neuron positions over time in mouse brain recordings.

Electrical fingerprints track single neurons over several months

The new approach, called UnitMatch, improves on past methods for analyzing large electrophysiological datasets, the researchers say.

By Claudia López Lloreda
1 November 2024 | 6 min read
A cortical neuron glows orange and red.

START method assembles brain’s wiring diagram by cell type

The new technique mapped the interactions of about 50 kinds of inhibitory neurons in the mouse visual cortex in finer detail than previous approaches.

By Holly Barker
31 October 2024 | 5 min read
Research image of fMRI scans on a black background.

Timing tweak turns trashed fMRI scans into treasure

Leveraging start-up “dummy scans,” which are typically discarded in imaging analyses, can shorten an experiment’s length and make data collection more efficient, a new study reveals.

By Angie Voyles Askham
30 October 2024 | 6 min listen

Explore more from The Transmitter

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The Transmitter’s favorite essays and columns of 2024

From sex differences in Alzheimer’s disease to enduring citation bias, experts weighed in on important scientific and practical issues in neuroscience.

By The Transmitter
23 December 2024 | 2 min read
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Say what? The Transmitter’s top quotes of 2024

“We’ve cured mouse-heimer’s thousands of times...”—find out who said this to a Transmitter reporter, and read our other favorite quotes from the past year.

By The Transmitter
23 December 2024 | 2 min read
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The Transmitter’s favorite podcasts of 2024

Our picks include a deep dive into dopamine, the role of PKMzeta in memory, and studying the stomatogastric ganglion.

By The Transmitter
23 December 2024 | 1 min read