Maternal infection

Recent articles

A pregnant woman seen in profile, sitting on the edge of a bed.

Maternal infection’s link to autism may be a mirage

Family-linked factors explain most associations between maternal illness and autism, a study of 1.1 million Danish children finds.

By Charles Q. Choi
6 March 2025 | 3 min read
Research image of microglia in mice.

Microglial overreaction to atypical neurons may drive autism

In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.

By Holly Barker
21 March 2024 | 5 min read
A research image of a mouse brain

Immune-activation model mice escape infantile amnesia, retain early memories

Male pups born to mothers treated with immune-stimulating molecules show autism-like behaviors and, unlike wildtype animals, do not lose memories formed during early life.

By Giorgia Guglielmi
11 January 2024 | 5 min read
A multiplexed image of human decidua.

Atlas charts cells of human placenta, uterus across early pregnancy

A new resource gives an unparalleled look at how fetal placental cells attach to the uterine wall and remodel maternal blood vessels to access nutrients.

By Emily Hayes
27 July 2023 | 4 min read
Research image of radial glial cells in a human brain organoid.

Immune molecule alters cellular makeup of human brain organoids

The changes may help explain the link between maternal infection and autism, though more research is needed.

By Charles Q. Choi
5 April 2023 | 5 min listen
Research image of the posterior insular cortex.

Maternal immune response dulls male rats’ social radar

Male rats prenatally exposed to a maternal immune response have atypical responses to other rats in distress, according to a new study.

By Angie Voyles Askham
27 March 2023 | 6 min listen
Illustration of a pregnant woman seated next to a large diagram of the brain featuring chromosomes, bacteria and other microbes.

The link between maternal infection and autism, explained

Having an infection during pregnancy is tied to a small increase in the chances of having an autistic child, but the connection may not be causal.

By Charles Q. Choi
13 December 2022 | 7 min read
Light micrograph of microglia cells stained with Rio Hortega’s silver carbonate method.

Autism’s sex bias tied to glial, immune cell gene expression

The function of microglia and astrocytes in the brain may mediate the intersection of sex-differential biology and autism biology.

By Angie Voyles Askham
22 November 2022 | 3 min read
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: COVID-19 conclusions; diagnosis duplication; oxytocin again

This month’s newsletter explores the pandemic’s effects on autism rates, trends in co-occurring mental health conditions, and the impact of intranasal oxytocin.

By Emily Harris
10 November 2022 | 5 min read
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: Medication timing; oxytocin amounts; sensory sameness

Parents’ health, treatment dosages and sensory perception feature in this month’s crop of null and replicated results.

By Emily Harris
13 October 2022 | 5 min read

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ABCD Study omits gender-identity data from latest release

The removal counteracts the goals of the longitudinal study by “pretending that some aspects of adolescent brain development don’t exist,” says sex differences researcher Nicola Grissom.

By Calli McMurray
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Leafcutter ants carrying leaves.

Neuropeptides reprogram social roles in leafcutter ants

The mechanisms that control the labor roles of ants may also be conserved in naked mole rats, a new study shows.

By Shaena Montanari
11 July 2025 | 7 min listen
Illustration of overlapping, multi-colored human head silhouettes.

Perspectives from the field: Opinions in autism research

This collection of Spectrum articles from the past 12 months highlights expert perspectives on autism’s heritability and its link to biological sex, the value of transdiagnostic frameworks, and the field’s future, among other topics.

By Daisy Yuhas
10 July 2025 | 3 min read