Manifolds

Recent articles

Tatiana Engel explains how to connect high-dimensional neural circuitry with low-dimensional cognitive functions

Neuroscientists have long sought to understand the relationship between structure and function in the vast connectivity and activity patterns in the brain. Engel discusses her modeling approach to discovering the hidden patterns that connect the two.

By Paul Middlebrooks
3 December 2025 | 1 min read
Illustration of a colorful, donut-shaped object resting on a distorted plane with its own topography.

Neural manifolds: Latest buzzword or pathway to understand the brain?

When you cut away the misconceptions, neural manifolds present a conceptually appropriate level at which systems neuroscientists can study the brain.

By Matthew Perich
2 October 2024 | 8 min read

Explore more from The Transmitter

Cortical organoids from the anterior (green) or posterior (red) cortex.

Polarized cortical organoids mimic the brain’s regional organization

The organoids show region-specific gene-expression changes that match those observed during fetal development.

By Holly Barker
24 September 2026 | 4 min read
Research diagram of gene expression.

Prefrontal cortex has three transcriptomic acts across human lifespan, new atlas suggests

Various genes show distinct exits and entrances with age in the open-source dataset, the largest of its kind to date.

By Siddhant Pusdekar
23 September 2026 | 5 min read

Microglia scoop out garbage from inside neurons

Through a newly identified process called skoupocytosis, neurons recruit the immune cells to remove cellular waste they find hard to deal with themselves.

By Siddhant Pusdekar
23 September 2026 | 0 min watch