Manifolds

Recent articles

Tatiana Engel explains how to connect high-dimensional neural circuitry with low-dimensional cognitive functions

Neuroscientists have long sought to understand the relationship between structure and function in the vast connectivity and activity patterns in the brain. Engel discusses her modeling approach to discovering the hidden patterns that connect the two.

By Paul Middlebrooks
3 December 2025 | 1 min read
Illustration of a colorful, donut-shaped object resting on a distorted plane with its own topography.

Neural manifolds: Latest buzzword or pathway to understand the brain?

When you cut away the misconceptions, neural manifolds present a conceptually appropriate level at which systems neuroscientists can study the brain.

By Matthew Perich
2 October 2024 | 8 min read

Explore more from The Transmitter

Trading places: What happens when neuroscience turns into machine learning, and machine learning turns into neuroscience?

Neuroscience has become increasingly concerned with prediction, and machine learning with causal explanation, with each field adopting methods from the other. I asked eight experts to weigh in on what we stand to learn from this exchange.

By Samuel Gershman
23 March 2026 | 22 min read
DNA strand

Exon-skipping approach boosts levels of key Rett syndrome protein

Deleting a small region of the MECP2 gene partially restored function in neurons derived from people with Rett-associated variants.

By Giorgia Guglielmi
20 March 2026 | 5 min read
Collage with a portrait of Caitlin Vander Weele in the foreground.

Frameshift: How Caitlin Vander Weele made science communication her business

Her favorite part of research was talking about it. So she left academia and turned that passion into a successful company.

By Katie Moisse
19 March 2026 | 6 min read