Locus coeruleus

Recent articles

Snoozing dragons stir up ancient evidence of sleep’s dual nature

Deep-sleep cycling between brain waves of higher and lower amplitude dates far back on the evolutionary tree, according to a new comparative study of mammals and reptiles.

By Lauren Schenkman
29 December 2025 | 0 min watch

The brain’s quiet conductor: How hidden cells fine-tune arousal

New research published today suggests that the pericoeruleus acts as a kind of micromanager of arousal, selectively inhibiting different subgroups of locus coeruleus neurons depending on the behavioral context.

By Mac Shine
7 May 2025 | 59 min watch
Three sleeping mice.

Fleeting sleep interruptions may help brain reset

Brief, seconds-long microarousals during deep sleep “ride on the wave” of locus coeruleus activity in mice and correlate with periods of waste clearing and memory consolidation, new research suggests.

By Shaena Montanari
13 January 2025 | 5 min read
Micrograph comparing locus coeruleus of 16p11.2 mutant mice and control mice show less active noradrenergic neurons in mutant mice.

Circuit flaw underlies motor learning issues in autism mouse model

Mice missing a copy of chromosomal region 16p11.2 are slow to learn motor tasks and have dysfunction in a brain circuit associated with stress and movement, according to a new study. Normalizing this circuit's activity corrects the learning deficit.

By Peter Hess
12 April 2021 | 4 min read

Explore more from The Transmitter

A human silhouette with lines connecting the brain to various organs.

PIEZO channels are opening the study of mechanosensation in unexpected places

The force-activated ion channels underlie the senses of touch and proprioception. Now scientists are using them as a tool to explore molecular mechanisms at work in internal organs, including the heart, bladder, uterus and kidney.

By Calli McMurray
30 January 2026 | 6 min read
US Department of Health and Human Services building.

Latest iteration of U.S. federal autism committee comes under fire

The new panel “represents a radical departure from all past rosters,” says autism researcher Helen Tager-Flusberg.

By Angie Voyles Askham
29 January 2026 | 9 min read
Progenitors cells in the medial ganglionic eminence become increasingly organized during development as rows of brain imaging progress from top to bottom.

‘Tour de force’ study flags fount of interneurons in human brain

The newly discovered cell type might point to the origins of the inhibitory imbalance linked to autism and other conditions.

By Holly Barker
29 January 2026 | 4 min read

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