Ion channels
Recent articles
Ketamine targets lateral habenula, setting off cascade of antidepressant effects
The drug’s affinity for overactive cells in the “anti-reward” region may help explain its rapid and long-lasting results.
Ketamine targets lateral habenula, setting off cascade of antidepressant effects
The drug’s affinity for overactive cells in the “anti-reward” region may help explain its rapid and long-lasting results.
Crafting tales of science with Theanne Griffith
A lifelong passion for writing helped the neuroscientist land a book deal and publish 15 chapter books for early readers, covering topics ranging from what the cerebellum does to how a cake bakes.
Crafting tales of science with Theanne Griffith
A lifelong passion for writing helped the neuroscientist land a book deal and publish 15 chapter books for early readers, covering topics ranging from what the cerebellum does to how a cake bakes.
CRISPR gives autism-linked genes a boost, rescues functioning
A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.
CRISPR gives autism-linked genes a boost, rescues functioning
A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
The legacy of William Catterall, ‘father of ion channels’
Catterall, who characterized the structure, function and regulation of sodium and calcium channels crucial for neuronal excitability, died last month at the age of 77.
The legacy of William Catterall, ‘father of ion channels’
Catterall, who characterized the structure, function and regulation of sodium and calcium channels crucial for neuronal excitability, died last month at the age of 77.
Top autism-linked genes join forces to shape synaptic plasticity
The protein products of ANK2 and SCN2A interact to regulate dendritic excitability.
Top autism-linked genes join forces to shape synaptic plasticity
The protein products of ANK2 and SCN2A interact to regulate dendritic excitability.
Unconventional optogenetics technique spurs long-lasting changes in neuronal activity
Conventional optogenetic manipulations to excite or inhibit neurons stop when the light switches off. A new approach makes the changes last.
Unconventional optogenetics technique spurs long-lasting changes in neuronal activity
Conventional optogenetic manipulations to excite or inhibit neurons stop when the light switches off. A new approach makes the changes last.
Building a better drug
Iama Therapeutics is hoping a new class of molecule will prove successful against an old target in autism.
Building a better drug
Iama Therapeutics is hoping a new class of molecule will prove successful against an old target in autism.
Mini biopsies point to source of lethal seizures in model mice
Interneurons that fail to propagate electrical signals in mice that model Dravet syndrome may cause the animals, like people with the autism-linked condition, to die suddenly.
Mini biopsies point to source of lethal seizures in model mice
Interneurons that fail to propagate electrical signals in mice that model Dravet syndrome may cause the animals, like people with the autism-linked condition, to die suddenly.
Model mice hint at sodium channel gene’s contribution to autism
Altered electrical activity in the neurons of mice with a mutated copy of SCN2A may explain the animals’ autism-like social behaviors.
Model mice hint at sodium channel gene’s contribution to autism
Altered electrical activity in the neurons of mice with a mutated copy of SCN2A may explain the animals’ autism-like social behaviors.
Explore more from The Transmitter
Video catches microglia in the act of synaptic pruning
Live cell imaging reveals the clearest picture yet of this elusive process. Whether it’s something these cells do regularly remains up for debate.
Video catches microglia in the act of synaptic pruning
Live cell imaging reveals the clearest picture yet of this elusive process. Whether it’s something these cells do regularly remains up for debate.
Gabriele Scheler reflects on the interplay between language, thought and AI
She discusses how verbal thought shapes cognition, why inner speech is foundational to human intelligence and what current artificial-intelligence models get wrong about language.
Gabriele Scheler reflects on the interplay between language, thought and AI
She discusses how verbal thought shapes cognition, why inner speech is foundational to human intelligence and what current artificial-intelligence models get wrong about language.
Accepting “the bitter lesson” and embracing the brain’s complexity
To gain insight into complex neural data, we must move toward a data-driven regime, training large models on vast amounts of information. We asked nine experts on computational neuroscience and neural data analysis to weigh in.
Accepting “the bitter lesson” and embracing the brain’s complexity
To gain insight into complex neural data, we must move toward a data-driven regime, training large models on vast amounts of information. We asked nine experts on computational neuroscience and neural data analysis to weigh in.