Interneurons
Recent articles
Ketamine targets lateral habenula, setting off cascade of antidepressant effects
The drug’s affinity for overactive cells in the “anti-reward” region may help explain its rapid and long-lasting results.
Ketamine targets lateral habenula, setting off cascade of antidepressant effects
The drug’s affinity for overactive cells in the “anti-reward” region may help explain its rapid and long-lasting results.
As circuits wire up, interneurons take cues from surrounding cells
The inhibitory cells’ development, diversity and abundance in the cortex is directed in part by pyramidal cells, a new preprint suggests.
As circuits wire up, interneurons take cues from surrounding cells
The inhibitory cells’ development, diversity and abundance in the cortex is directed in part by pyramidal cells, a new preprint suggests.
Synaptic anomalies in autistic people support imbalance hypothesis
Increased excitatory and decreased inhibitory synapses in the prefrontal cortex of autistic people suggest broader impacts on brain function and connectivity.
Synaptic anomalies in autistic people support imbalance hypothesis
Increased excitatory and decreased inhibitory synapses in the prefrontal cortex of autistic people suggest broader impacts on brain function and connectivity.
Cortical interneurons derive differently in human brains
Excitatory neurons and some inhibitory neurons in the adult human cortex share parents, challenging the longstanding idea that the two cell types have different origins.
Cortical interneurons derive differently in human brains
Excitatory neurons and some inhibitory neurons in the adult human cortex share parents, challenging the longstanding idea that the two cell types have different origins.
Vast diversity of human brain cell types revealed in trove of new datasets
The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.
Vast diversity of human brain cell types revealed in trove of new datasets
The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.
Uncertainty and excitement surround one company’s cell therapy for epilepsy
After 10 years of work, Neurona may have the data to quiet its skeptics. But its ongoing clinical trial will be the ultimate test.
Uncertainty and excitement surround one company’s cell therapy for epilepsy
After 10 years of work, Neurona may have the data to quiet its skeptics. But its ongoing clinical trial will be the ultimate test.
‘VIP’ interneurons may drive autism traits in Dravet syndrome
The inhibitory cells misfire and contribute to social difficulties in mice that model the syndrome.
‘VIP’ interneurons may drive autism traits in Dravet syndrome
The inhibitory cells misfire and contribute to social difficulties in mice that model the syndrome.
Tweaks to autism-linked pathway tilt circuits’ signaling balance
Altered expression of TSC2 and the mTOR pathway reshape the formation of certain synapses between inhibitory and excitatory neurons in mice.
Tweaks to autism-linked pathway tilt circuits’ signaling balance
Altered expression of TSC2 and the mTOR pathway reshape the formation of certain synapses between inhibitory and excitatory neurons in mice.
Multi-omics study captures CNTNAP2’s far-ranging effects
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
Multi-omics study captures CNTNAP2’s far-ranging effects
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
One-rosette technique grows well-organized organoids
The method yields complex organoids that more closely mimic embryonic brain development than do those cultured in other ways.
One-rosette technique grows well-organized organoids
The method yields complex organoids that more closely mimic embryonic brain development than do those cultured in other ways.
Explore more from The Transmitter
New tool may help untangle downstream effects of autism-linked genes
The statistical approach helps scientists better control for both measured and unmeasured confounders in gene-expression data, revealing causal relationships between autism-linked genetic variants and downstream cellular effects, such as impaired neuron development.
New tool may help untangle downstream effects of autism-linked genes
The statistical approach helps scientists better control for both measured and unmeasured confounders in gene-expression data, revealing causal relationships between autism-linked genetic variants and downstream cellular effects, such as impaired neuron development.
Video catches microglia in the act of synaptic pruning
Live cell imaging reveals the clearest picture yet of this elusive process. Whether it’s something these cells do regularly remains up for debate.
Video catches microglia in the act of synaptic pruning
Live cell imaging reveals the clearest picture yet of this elusive process. Whether it’s something these cells do regularly remains up for debate.
Gabriele Scheler reflects on the interplay between language, thought and AI
She discusses how verbal thought shapes cognition, why inner speech is foundational to human intelligence and what current artificial-intelligence models get wrong about language.
Gabriele Scheler reflects on the interplay between language, thought and AI
She discusses how verbal thought shapes cognition, why inner speech is foundational to human intelligence and what current artificial-intelligence models get wrong about language.