Immune system

Recent articles

Illustration of a body, brain visible through a transparent head, looking at orange circles over its hands.

Rethinking mental health: The body’s impact on the brain

Mounting evidence illustrates how peripheral molecules can influence brain function, offering new therapeutic targets.

By Georgia E. Hodes
11 February 2025 | 6 min read
Research image of mouse cells.

Immune cell interlopers breach—and repair—brain barrier in mice

The choroid plexus, the protective network of blood vessels and epithelial cells that line the brain’s ventricles, recruits neutrophils and macrophages during inflammation, a new study shows.

By Claudia López Lloreda
20 November 2024 | 6 min listen
Research image of microglia in mice.

Microglial overreaction to atypical neurons may drive autism

In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.

By Holly Barker
21 March 2024 | 5 min read
A research image of a mouse brain

Immune-activation model mice escape infantile amnesia, retain early memories

Male pups born to mothers treated with immune-stimulating molecules show autism-like behaviors and, unlike wildtype animals, do not lose memories formed during early life.

By Giorgia Guglielmi
11 January 2024 | 5 min read
A multiplexed image of human decidua.

Atlas charts cells of human placenta, uterus across early pregnancy

A new resource gives an unparalleled look at how fetal placental cells attach to the uterine wall and remodel maternal blood vessels to access nutrients.

By Emily Hayes
27 July 2023 | 4 min read

‘wildDISCO’ cocktail yields whole-body maps of mouse neurons and more

A new technique used to create see-through rodents can help scientists analyze how the nervous system interacts with other body systems.

By Charles Q. Choi
20 July 2023 | 4 min read
Research image comparing microglia with serotonin receptors to those without.

Serotonin powers pruning of developing brain circuits in mice

Mice with microglia missing receptors for the neurotransmitter serotonin since birth have too many synapses and show social difficulties in adulthood.

By Katie Moisse
28 June 2023 | 5 min listen
Research image of the posterior insular cortex.

Maternal immune response dulls male rats’ social radar

Male rats prenatally exposed to a maternal immune response have atypical responses to other rats in distress, according to a new study.

By Angie Voyles Askham
27 March 2023 | 6 min listen
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: Registered reports; motor measurements; viral DNA

In this edition of Null and Noteworthy, Spectrum talks with a Nature editor about the journal’s move to publish more null results.

By Laura Dattaro
16 March 2023 | 4 min read
A sliced section of a human brain is displayed for a photograph.

Immunity-linked genes expressed differently in brains of autistic people

Postmortem brain samples from people with one of six conditions, including autism, show distinct signatures of over- and underexpression of immune genes.

By Laura Dattaro
6 January 2023 | 4 min read

Explore more from The Transmitter

Illustration of a paper draft covered in notes and sign-off signatures, and surrounded by many hands reaching towards it.

The last two-author neuroscience paper?

Author lists on papers have ballooned, and it’s getting hard to discern contribution.

By Lydia Denworth
25 February 2025 | 3 min read
Illustration of an open journal featuring lines of text and small illustrations of eyes and mouths.

Attention and IQ link; AUTS2-related syndrome; Glyx-13 for fragile X

Here is a roundup of autism-related news and research spotted around the web for the week of 24 February.

By Jill Adams
25 February 2025 | 1 min read
A man stands in front of a ladder; a woman to his right stands in front of an identical ladder missing every rung except the top and bottom rungs.

Adapt or die: Safeguarding the future of diversity and inclusion funding in neuroscience

As diversity and inclusion funding initiatives crumble, we as neuroscientists need to change how we write grants, better communicate the economic benefits of our work and engage in constructive conflict when necessary.

By David Barker
25 February 2025 | 6 min read