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Illustration of ketamine blocking open ion channels in active NMDA receptors, quieting the cells and disrupting downstream signaling involved in depression.

Ketamine targets lateral habenula, setting off cascade of antidepressant effects

The drug’s affinity for overactive cells in the “anti-reward” region may help explain its rapid and long-lasting results.

By Olivia Gieger
4 September 2024 | 6 min read
A young boy sits alone on a bench in a playground.

Mental health issues emerge with shifts in autism traits across childhood

Anxiety and other challenges autistic children experience may stem from an increase in social-communication issues and a decrease in repetitive behaviors from ages 6 to 11.

By Charles Q. Choi
27 September 2023 | 3 min read
Research image comparing microglia with serotonin receptors to those without.

Serotonin powers pruning of developing brain circuits in mice

Mice with microglia missing receptors for the neurotransmitter serotonin since birth have too many synapses and show social difficulties in adulthood.

By Katie Moisse
28 June 2023 | 5 min listen
Research image of zebrafish forebrains.

Autism-related genes converge on microglia and dopamine in zebrafish

The findings add to the growing evidence that genes with disparate functions can play similar roles in brain development.

By Peter Hess
12 May 2023 | 4 min read
Research image shows elevated expression of certain genes, shown in pink and green, along with expected gene expression, shown in blue.

Autism-linked MYT1L mutations prompt ‘identity crisis’ in budding brain cells

Both human and mouse progenitor cells with the alterations struggle to become neurons and instead express genes that are typically active only in muscle or the heart.

By Laura Dattaro
14 February 2023 | 5 min read
Mouse neurons in red and pink on black.

Mouse model reveals root of breathing issues in rare form of autism

Dysfunctional circuits and a rogue sodium channel in the brainstem may explain the disordered breathing pattern seen in children with Pitt-Hopkins syndrome, a form of autism.

By Anna Goshua
5 November 2021 | 4 min read
Two colorful mouse neurons seen side by side on black, one has a mutation.

Precocious neurons may stunt brain growth in rare form of autism

The first animal model of MYT1L syndrome suggests that fast-maturing neurons lead to the unusually small brains, social deficits and other traits seen in people with the condition.

By Peter Hess
5 October 2021 | 5 min read

Stimulant restores cell signaling, eases behavior issues in animals missing autism gene

Worms and zebrafish missing both copies of the gene CHD7 have disrupted cellular signaling, a dearth of inhibitory neurons and behavior changes — all of which are reversed by the stimulant drug ephedrine.

By Peter Hess
28 May 2021 | 4 min read
Neurons in a macaque cortex express parvalbumin in red.

Virus-based method manipulates inhibitory neurons in brains

A new viral tool can selectively control different types of neurons that dampen brain activity in rodents, monkeys and people.

By Jonathan Moens
9 September 2020 | 4 min read
Young boy biting his fingernails, looking anxiously out the window.

Long-term study tracks persistence of self-harm in autistic people

Autistic people who are hyperactive or have difficulty controlling their own impulses are the most likely to show ongoing self-injury.

By Chloe Williams
21 February 2020 | 4 min read

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Rajesh Rao reflects on predictive brains, neural interfaces and the future of human intelligence

Twenty-five years ago, Rajesh Rao proposed a seminal theory of how brains could implement predictive coding for perception. His modern version zeroes in on actions.

By Paul Middlebrooks
18 December 2024 | 97 min listen

In memoriam: Yves Frégnac, influential and visionary French neuroscientist

Frégnac, who died on 18 October at the age of 73, built his career by meeting neuroscience’s complexity straight on.

By Bahar Gholipour
18 December 2024 | 9 min read
Illustration shows a solitary figure moving through a green and blue field of dots moving at different rates.

Explaining ‘the largest unexplained number in brain science’: Q&A with Markus Meister and Jieyu Zheng

The human brain takes in sensory information roughly 100 million times faster than it can respond. Neuroscientists need to explore this perceptual paradox to better understand the limits of the brain, Meister and Zheng say.

By Claudia López Lloreda
17 December 2024 | 8 min read