Hippocampus

Recent articles

Research image of portions of the adult dentate gyrus.

Machine learning spots neural progenitors in adult human brains

But the finding has not settled the long-standing debate over the existence and extent of neurogenesis during adulthood, says Yale University neuroscientist Juan Arellano.

By Claudia López Lloreda
3 July 2025 | 7 min listen
Research image of excitatory neurons in the mouse hippocampus.

Spatial learning circuitry fluctuates in step with estrous cycle in mice

Cyclic shifts in estradiol levels coincide with changes in dendritic spine density and the activity of place cells in the CA1 region of the hippocampus, a new study shows.

By Sydney Wyatt
25 June 2025 | 6 min listen

Expanded view of hippocampal function comes into focus

After decades of debate, the region’s role is being rewritten. Rather than using sensory input to simply log key points in time and space, the hippocampus may serve to contextualize our experiences and memories—and ultimately make predictions about the future.

By Natalia Mesa
24 June 2025 | 11 min listen
Photograph of a chickadee.

Gazing at a location from afar activates place cells in chickadees

The results help explain how the hippocampus can recall information about a place without an animal physically revisiting it.

By Marta Hill
13 June 2025 | 6 min listen
Illustration of synapse-like threads connecting in various ways.

Learning in living mice defies classic synaptic plasticity rule

Donald Hebb’s theory—memorably summarized as “cells that fire together, wire together”—does not explain the shifting hippocampal connections in mice learning to navigate a virtual environment, according to a new study.

By Sydney Wyatt
28 May 2025 | 6 min listen
Image of brain cell activity in rat brains.

Sleep doesn’t just consolidate memories; it actively shapes them

The rapid eye movement (REM) phase preserves newly acquired memories, but deeper non-REM sleep helps to adapt and update them, according to “heroic” day-long electrode recordings in rats.

By Giorgia Guglielmi
6 May 2025 | 6 min listen
Cognitive neuroscientist Nick Turk-Browne helps an infant into an fMRI machine.

What infant fMRI is revealing about the developing mind

Cognitive neuroscientists have finally clocked how to perform task-based functional MRI experiments in awake babies—long known for their inability to lie still or take direction. Next, they aim to watch cognition take shape and settle a debate about our earliest memories—with one group publishing a big clue today.

By Calli McMurray
20 March 2025 | 12 min read
A mouse sits on a gloved hand.

Molecular changes after MECP2 loss may drive Rett syndrome traits

Knocking out the gene in adult mice triggered up- and down-regulated expression of myriad genes weeks before there were changes in neuronal function.

By Chloe Williams
20 March 2025 | 5 min read
Patient being administered an EEG test.

Single-neuron recordings are helping to unravel complexities of human cognition

As this work begins to bear fruit, researchers “are becoming less afraid to ask very difficult questions that you can uniquely ask in people.”

By Claudia López Lloreda
14 March 2025 | 10 min listen

Alison Preston explains how our brains form mental frameworks for interpreting the world

Preston discusses her research examining differences in how children, teenagers and adults integrate new information into their memories.

By Paul Middlebrooks
12 March 2025 | 90 min listen

Explore more from The Transmitter

ABCD Study omits gender-identity data from latest release

The removal counteracts the goals of the longitudinal study by “pretending that some aspects of adolescent brain development don’t exist,” says sex differences researcher Nicola Grissom.

By Calli McMurray
11 July 2025 | 4 min read
Leafcutter ants carrying leaves.

Neuropeptides reprogram social roles in leafcutter ants

The mechanisms that control the labor roles of ants may also be conserved in naked mole rats, a new study shows.

By Shaena Montanari
11 July 2025 | 7 min listen
Illustration of overlapping, multi-colored human head silhouettes.

Perspectives from the field: Opinions in autism research

This collection of Spectrum articles from the past 12 months highlights expert perspectives on autism’s heritability and its link to biological sex, the value of transdiagnostic frameworks, and the field’s future, among other topics.

By Daisy Yuhas
10 July 2025 | 3 min read