Glymphatic system

Recent articles

Three sleeping mice.

Fleeting sleep interruptions may help brain reset

Brief, seconds-long microarousals during deep sleep “ride on the wave” of locus coeruleus activity in mice and correlate with periods of waste clearing and memory consolidation, new research suggests.

By Shaena Montanari
13 January 2025 | 5 min read
Illustration of a lab with a smoking crater in the middle of the floor.

The Transmitter’s favorite features of 2024

Our chosen stories include tales about research misconduct in the lab, a neuroscientist working at the end of the world, and the passing of neuroanatomy’s “great-grandfather,” Harvey Karten.

By The Transmitter
23 December 2024 | 2 min read
New method reignites controversy over brain clearance during sleep.

New method reignites controversy over brain clearance during sleep

Tracers injected directly into mouse brain tissue instead of the cerebrospinal fluid show that brain clearance slows during sleep and under anesthesia, according to a study published last week—but proponents of the glymphatic system theory take issue with the technique.

By Elissa Welle
22 May 2024 | 8 min read
Maiken Nedergaard, Britta Engelhardt and Christer Betsholtz on a floating rock island with university facilities and abstract shapes.

Maiken Nedergaard’s power of disruption

The award-winning researcher’s discoveries have changed the way we think about the brain; that’s exactly what her critics dislike.

By Emily Sohn
26 February 2024 | 26 min listen

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Researcher holds a mouse perched on a glass cylinder.

NIH proposal sows concerns over future of animal research, unnecessary costs

The new NIH policy calls for greater incorporation of new approach methodologies in all future Notices of Funding Opportunities related to animal model systems.

By Claudia López Lloreda
15 July 2025 | 5 min read

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By Jill Adams
15 July 2025 | 2 min read
A group of researchers reading while institutions crumble in the background, and giant mice appear on the horizon.

Fear and loathing on study section: Reviewing grant proposals while the system is burning

As grants are canceled, delayed and subject to general uncertainty, participating in study sections can feel futile. But it’s more important than ever.

By John Tuthill
14 July 2025 | 8 min read