FMR1
Recent articles
Sounding the alarm on pseudoreplication: Q&A with Constantinos Eleftheriou and Peter Kind
Most studies of neurological disorders in mice erroneously treat multiple samples from a single animal as independent replicates, according to a new analysis. But scientists and journals can take steps to curb this practice.
Sounding the alarm on pseudoreplication: Q&A with Constantinos Eleftheriou and Peter Kind
Most studies of neurological disorders in mice erroneously treat multiple samples from a single animal as independent replicates, according to a new analysis. But scientists and journals can take steps to curb this practice.
Understanding fragile X syndrome
Just in time for Fragile X Awareness Month, The Transmitter rounds up notable coverage.
Understanding fragile X syndrome
Just in time for Fragile X Awareness Month, The Transmitter rounds up notable coverage.
Noisy brain may underlie some of autism’s sensory features
Random fluctuations in neuronal activity are more variable in a fragile X mouse model than in wildtype mice.
Noisy brain may underlie some of autism’s sensory features
Random fluctuations in neuronal activity are more variable in a fragile X mouse model than in wildtype mice.
Skewed signaling in striatum may spawn repetitive behaviors
Synaptic changes in the brain region could drive a core trait of fragile X syndrome, a new mouse study suggests.
Skewed signaling in striatum may spawn repetitive behaviors
Synaptic changes in the brain region could drive a core trait of fragile X syndrome, a new mouse study suggests.
Neuronal deafness to stress may add to protein surplus in fragile X
A protective pathway that pauses protein synthesis is muted in a mouse model of fragile X syndrome, according to a new study.
Neuronal deafness to stress may add to protein surplus in fragile X
A protective pathway that pauses protein synthesis is muted in a mouse model of fragile X syndrome, according to a new study.
Unknown isoform adds twist to theory of fragile X origins
Contrary to conventional wisdom, most people with fragile X syndrome express the FMR1 gene — albeit improperly.
Unknown isoform adds twist to theory of fragile X origins
Contrary to conventional wisdom, most people with fragile X syndrome express the FMR1 gene — albeit improperly.
New gene-editing method flags fragile X mutation for repair
The approach prompts cultured cells to correct the genetic mutation in fragile X syndrome using their own DNA repair system, but it still needs to be tested further.
New gene-editing method flags fragile X mutation for repair
The approach prompts cultured cells to correct the genetic mutation in fragile X syndrome using their own DNA repair system, but it still needs to be tested further.
Astrocytes fuel erratic firing in fragile X neurons
A shift in astrocyte secretions may explain the atypical firing patterns of neurons derived from people with fragile X syndrome.
Astrocytes fuel erratic firing in fragile X neurons
A shift in astrocyte secretions may explain the atypical firing patterns of neurons derived from people with fragile X syndrome.
Company on brink takes psilocybin to trial for fragile X syndrome
The phase 2A trial has its detractors despite positive animal results and is being sponsored by a company that is struggling financially.
Company on brink takes psilocybin to trial for fragile X syndrome
The phase 2A trial has its detractors despite positive animal results and is being sponsored by a company that is struggling financially.
Going on Trial: Orphan drugs; CBD; bumetanide
This month’s newsletter takes a close look at the orphan drug program in the United States, several cannabis-based therapies and a secondary analysis of bumetanide, among other new developments in autism-related drug trials.
Going on Trial: Orphan drugs; CBD; bumetanide
This month’s newsletter takes a close look at the orphan drug program in the United States, several cannabis-based therapies and a secondary analysis of bumetanide, among other new developments in autism-related drug trials.
Explore more from The Transmitter
Is it time for neuroscience to shift its focus from a computational mind to a navigating mind?
Andrea Hiott explains her navigational approach to the mind, and why now is the time to embrace seemingly paradoxical findings in neuroscience.
Is it time for neuroscience to shift its focus from a computational mind to a navigating mind?
Andrea Hiott explains her navigational approach to the mind, and why now is the time to embrace seemingly paradoxical findings in neuroscience.
Human brain organoids come of age—but still have room to grow
The U.S. government has touted organoids as an alternative to animals for studying the brain. The model has improved since its debut in 2013, but scientists are still working to overcome key limitations: immaturity, consistency and the lack of vascularization.
Human brain organoids come of age—but still have room to grow
The U.S. government has touted organoids as an alternative to animals for studying the brain. The model has improved since its debut in 2013, but scientists are still working to overcome key limitations: immaturity, consistency and the lack of vascularization.
Finding neuroheterogeneity’s sweet spot
Once thought to be detrimental to memory processing, neuronal diversity—at the right ‘Goldilocks’ dose—is a new boon to theoretical neuroscience.
Finding neuroheterogeneity’s sweet spot
Once thought to be detrimental to memory processing, neuronal diversity—at the right ‘Goldilocks’ dose—is a new boon to theoretical neuroscience.