Female protective effect

Recent articles

Research image of patterns of expression of autosomal genes.

Gene activity in human cortex shows striking sex differences

The results mark a “dramatic shift” in how neuroscientists think about sex differences, and they may help explain sex biases in certain neurodegenerative and neurodevelopmental conditions.

By Lauren Schenkman
5 May 2026 | 5 min read
Research image highlighting different brain regions.

X marks the spot in search for autism variants

Genetic variants on the X chromosome, including those in the gene DDX53, contribute to autism’s gender imbalance, two new studies suggest.

By Holly Barker
16 January 2025 | 6 min read
Illustration of children looking at a gigantic set of building blocks, some of which display genetic sequences on their surfaces.

Autism is more heritable in boys than in girls

If boys have greater inherited liability for autism, the female protective effect may not fully explain the sex difference in prevalence.

Research illustration groups genes by their effects on brain cell types.

Giant analysis reveals how autism-linked genes affect brain cell types

Genes that predispose people to autism account for a large portion of the neuronal and glial cell changes seen in those with the condition.

By Charles Q. Choi
20 June 2024 | 5 min read
Composite research image of organoids at several stages of development.

Genetic background sways effects of autism-linked mutation

Experiments offer clues to why certain mutations are associated with autism in some people and not others.

By Charles Q. Choi
18 May 2023 | 4 min read
Illustration of an X chromosome against a black background.

X-chromosome variants help explain autism’s sex bias

The rare variants are also linked to ADHD and Tourette syndrome, two other conditions that disproportionately affect boys and men.

By Charles Q. Choi
24 October 2022 | 4 min read

Explore more from The Transmitter

Speech bubbles progress from light- to dark- colored.

Amid funding uncertainty, neuroscientists report a mix of cynicism, persistence

Two years into one of the most tumultuous tenures in U.S. federal funding, researchers outline how they are coping with ongoing changes and reflect on the impact these changes are having on the system more broadly.

By Emily Singer
28 August 2026 | 5 min read
Stages of neurodegeneration: Neurofibrillary tangles at different stages of neurodegeneration are labeled with phosphorylated tau antibodies (green and blue).

Reimagining Mexico’s brain bank

Since Alzheimer’s disease researcher José Luna-Muñoz assumed leadership of the facility—Latin America’s oldest—in 2011, he has been acquiring additional tissue types and is working to expand donor recruitment to rural areas.

By Alejandra Manjarrez
28 August 2026 | 7 min read

Revealing how crabs make their escape

Houdini-like Neohelice granulata offers a rare opportunity to record intracellularly from awake, behaving animals.

By Natalia Mesa
28 August 2026 | 0 min watch