DYRK1A
Recent articles
Nearly 400 compounds affect behaviors tied to autism-linked genes in zebrafish
Estropipate, paclitaxel and levocarnitine altered behaviors tied to SCN2A and DYRK1A variants specifically, a new open-source platform revealed.
Nearly 400 compounds affect behaviors tied to autism-linked genes in zebrafish
Estropipate, paclitaxel and levocarnitine altered behaviors tied to SCN2A and DYRK1A variants specifically, a new open-source platform revealed.
Some social issues in DYRK1A model mice stem from faulty inhibitory circuits
Alterations in inhibitory circuits and difficulties in social recognition characterize mice missing one copy of DYRK1A, a gene linked to autism.
Some social issues in DYRK1A model mice stem from faulty inhibitory circuits
Alterations in inhibitory circuits and difficulties in social recognition characterize mice missing one copy of DYRK1A, a gene linked to autism.
Autism-related genes converge on microglia and dopamine in zebrafish
The findings add to the growing evidence that genes with disparate functions can play similar roles in brain development.
Autism-related genes converge on microglia and dopamine in zebrafish
The findings add to the growing evidence that genes with disparate functions can play similar roles in brain development.
Autism and the cell’s antennae
Many autism-linked genes are somehow tied to cilia, the tiny hair-like sensors that stud a cell’s surface. But the question remains whether, and how, cilia differences contribute to the condition.
Autism and the cell’s antennae
Many autism-linked genes are somehow tied to cilia, the tiny hair-like sensors that stud a cell’s surface. But the question remains whether, and how, cilia differences contribute to the condition.
Screening zebrafish autism models: A quick take at SfN with Ellen Hoffman
Zebrafish with mutations in 10 different autism-linked genes show a range of unique and shared phenotypes.
Screening zebrafish autism models: A quick take at SfN with Ellen Hoffman
Zebrafish with mutations in 10 different autism-linked genes show a range of unique and shared phenotypes.
Mapping the futures of autistic children
Researchers can roughly project what autistic children's lives will look like years down the road. But how good is their crystal ball — and what are its benefits?
Mapping the futures of autistic children
Researchers can roughly project what autistic children's lives will look like years down the road. But how good is their crystal ball — and what are its benefits?
Jump-starting growth signaling reverses microcephaly in autism mouse model
A genetic therapy and an existing drug both restore typical brain size in mice missing DYRK1A, a top autism candidate gene, in the cerebral cortex, a new study shows. The animals typically have smaller brains than controls.
Jump-starting growth signaling reverses microcephaly in autism mouse model
A genetic therapy and an existing drug both restore typical brain size in mice missing DYRK1A, a top autism candidate gene, in the cerebral cortex, a new study shows. The animals typically have smaller brains than controls.
How microscopic ‘condensates’ in cells might contribute to autism
A controversial idea about how cells compartmentalize their contents into droplets — like beads of oil in water — could be key to understanding autism, says Julie Forman-Kay.
How microscopic ‘condensates’ in cells might contribute to autism
A controversial idea about how cells compartmentalize their contents into droplets — like beads of oil in water — could be key to understanding autism, says Julie Forman-Kay.
Mutations in frogs point to autism genes’ shared role in neurogenesis
Mutations in any of 10 autism-linked genes in frogs lead to the same overabundance of brain cells that develop into neurons; the sex hormone estrogen lowers this excess.
Mutations in frogs point to autism genes’ shared role in neurogenesis
Mutations in any of 10 autism-linked genes in frogs lead to the same overabundance of brain cells that develop into neurons; the sex hormone estrogen lowers this excess.
How families are driving the study of autism genes
Parents of children with rare autism-linked mutations are banding together for support and to join forces with scientists, accelerating the pace of research.
How families are driving the study of autism genes
Parents of children with rare autism-linked mutations are banding together for support and to join forces with scientists, accelerating the pace of research.
Explore more from The Transmitter
‘Unbelievably beautiful’ evidence extends Nobel Prize-winning model of vision
Orientation tuning—the ability to distinguish a horizontal line from a vertical one or something in between—originates in the visual cortex, according to new mouse synapse imaging experiments.
‘Unbelievably beautiful’ evidence extends Nobel Prize-winning model of vision
Orientation tuning—the ability to distinguish a horizontal line from a vertical one or something in between—originates in the visual cortex, according to new mouse synapse imaging experiments.
Bringing basic biology back to INSAR
As the International Society for Autism Research has grown over the past two decades, basic science has become less central, Christine Wu Nordahl says. This year, she and other meeting organizers aimed to change that.
Bringing basic biology back to INSAR
As the International Society for Autism Research has grown over the past two decades, basic science has become less central, Christine Wu Nordahl says. This year, she and other meeting organizers aimed to change that.
Every neuroscience lab needs an ethicist
The ethics issues that arise in neuroscience research are usually novel, unresolved and understudied. Embedding ethicists in labs helps scientists navigate these challenges and develop strategies in real time to prevent harm.
Every neuroscience lab needs an ethicist
The ethics issues that arise in neuroscience research are usually novel, unresolved and understudied. Embedding ethicists in labs helps scientists navigate these challenges and develop strategies in real time to prevent harm.