Dendrites

Recent articles

Dendritic spine images.

Targeting NMDA receptor subunit reverses fragile X traits in mice

The subunit acts as a “volume control” on signaling that shapes the density of dendritic spines, the new work suggests.

By Angie Voyles Askham
6 March 2025 | 5 min read
Research image of excitatory synapses in the prefrontal cortex.

Synaptic anomalies in autistic people support imbalance hypothesis

Increased excitatory and decreased inhibitory synapses in the prefrontal cortex of autistic people suggest broader impacts on brain function and connectivity.

By Giorgia Guglielmi
27 June 2024 | 4 min read
Neural progenitor cells in a culture medium, color-enhanced scanning electron micrograph (SEM).

Autism subgroups converge on cell growth pathway

Faulty mTOR signaling, implicated in syndromic forms of autism, also hinders cells grown from people with idiopathic autism or autism-linked deletions on chromosome 16.

By Angie Voyles Askham
2 April 2024 | 5 min listen

Neurons making memories shush their neighbors

When neurons strengthen their synapses, they “infect” surrounding cells with a virus-like protein to weaken those cells’ excitatory connections, according to a new preprint.

By Holly Barker
22 March 2024 | 5 min read
Research image of microglia in mice.

Microglial overreaction to atypical neurons may drive autism

In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.

By Holly Barker
21 March 2024 | 5 min read
A research image of neuronal dendrites in mice.

Top autism-linked genes join forces to shape synaptic plasticity

The protein products of ANK2 and SCN2A interact to regulate dendritic excitability.

By Holly Barker
29 January 2024 | 5 min read
Research image of mutations in mouse cortical neurons.

Mutations in multipurpose gene deal dendrites a double whammy

The mutations disrupt protein translation as well as the cell’s skeleton, according to a new study.

By Holly Barker
4 October 2023 | 5 min listen
Research image of neurons.

Abundant motor proteins disrupt cries in FOXP2 mice

Knocking down the gene that codes for the proteins normalizes the vocalizations.

By Laura Dattaro, Maaisha Osman
28 July 2023 | 3 min read

Autism’s ties to the cell skeleton

Many genes related to the condition play a role in the internal scaffolding of cells, and cytoskeletal disruptions can affect neurodevelopment and behavior.

By Giorgia Guglielmi
22 June 2023 | 7 min read

Wiring map reveals how larval fruit fly brain converts sensory signals to movement

The map diagrams more than half a million neuronal connections in the first complete connectome of Drosophila and holds clues about which brain architectures best support learning.

By Laura Dattaro
9 March 2023 | 5 min listen

Explore more from The Transmitter

It’s time to examine neural coding from the message’s point of view

In studying the brain, we almost always take the neuron’s perspective. But we can gain new insights by reorienting our frame of reference to that of the messages flowing over brain networks.

By Daniel Graham
1 April 2025 | 0 min watch
Illustration of an open journal featuring lines of text and small illustrations of eyes and mouths.

Autism traits, mental health conditions interact in sex-dependent ways in early development

Here is a roundup of autism-related news and research spotted around the web for the week of 31 March.

By Jill Adams
1 April 2025 | 2 min read
Research image of an assembloid.

Organoids and assembloids offer a new window into human brain

These sophisticated 3D cultures reveal previously inaccessible stages of human brain development and enable the systematic study of disease genes.

By Sergiu P. Pasca
31 March 2025 | 6 min read