Defining cell types

Recent articles

This series explores how new high-throughput technologies are changing the way we define brain-cell types—and the challenges that remain.

Illustration of flocking birds.

From genes to dynamics: Examining brain cell types in action may reveal the logic of brain function

Defining brain cell types is no longer a matter of classification alone, but of embedding their genetic identities within the dynamical organization of population activity.

By Liset M. de la Prida
9 February 2026 | 6 min read
A playful cellular map features top-down and bottom-up views of the human brain arranged side-by-side as if they were the earth’s two hemispheres in an old-fashioned map of the world. The brains are colored to suggest land masses and bodies of water.

Knowledge graphs can help make sense of the flood of cell-type data

These tools, widely used in the technology industry, could provide a foundation for the study of brain circuits.

By Michael Hawrylycz
28 May 2024 | 7 min read
Illustration of neurons against a blue background.

Where do cell states end and cell types begin?

High-throughput transcriptomics offers powerful new methods for defining different types of brain cells. But we need to think more explicitly about how we use these data to distinguish a cell’s permanent identity from its transient states.

By Anne E. West
22 April 2024 | 6 min read
An illustration of a gold circle and wavy blue plants.

Building a brain: How does it generate its exquisite diversity of cells?

High-throughput technologies have revealed new insights into how the brain develops. But a truly comprehensive map of neurodevelopment requires further advances.

By Tomasz Nowakowski, Karthik Shekhar
18 March 2024 | 6 min read
A diagram of many types of cells

Welcome to the second single-cell revolution: New high-throughput technologies are transforming how we define neurons

This ongoing essay series will explore questions these technologies raise, as well as opportunities they provide for understanding development, evolution and disease.

By Joshua R. Sanes
29 January 2024 | 7 min read

Get notified every time a new column in this series is published.

Explore more from The Transmitter

Argentine protesters condemn science funding shortfall

Demonstrators across the country called for the government to increase public university salaries and funding for scientific research.

neural networks illustration.

This paper changed my life: Appreciating John Hopfield’s brilliant neural network

In a 1982 paper, the Nobel laureate created his namesake recurrent neural network—work that taught Maria Geffen to always ground research questions in biology.

By Maria Geffen
15 May 2026 | 5 min read
dialogue illustration.

How basic neuroscientists can connect with autistic people and their communities

A first-of-its-kind workshop offers a template for autism researchers who want to incorporate community perspectives into their work.

By Juliana Chase, Hannah R. Monday, Lea Witkowsky
14 May 2026 | 6 min read