Defining cell types

Recent articles

This series explores how new high-throughput technologies are changing the way we define brain-cell types—and the challenges that remain.

A playful cellular map features top-down and bottom-up views of the human brain arranged side-by-side as if they were the earth’s two hemispheres in an old-fashioned map of the world. The brains are colored to suggest land masses and bodies of water.

Knowledge graphs can help make sense of the flood of cell-type data

These tools, widely used in the technology industry, could provide a foundation for the study of brain circuits.

By Michael Hawrylycz
28 May 2024 | 7 min read
Illustration of neurons against a blue background.

Where do cell states end and cell types begin?

High-throughput transcriptomics offers powerful new methods for defining different types of brain cells. But we need to think more explicitly about how we use these data to distinguish a cell’s permanent identity from its transient states.

By Anne E. West
22 April 2024 | 6 min read
An illustration of a gold circle and wavy blue plants.

Building a brain: How does it generate its exquisite diversity of cells?

High-throughput technologies have revealed new insights into how the brain develops. But a truly comprehensive map of neurodevelopment requires further advances.

By Tomasz Nowakowski, Karthik Shekhar
18 March 2024 | 6 min read
A diagram of many types of cells

Welcome to the second single-cell revolution: New high-throughput technologies are transforming how we define neurons

This ongoing essay series will explore questions these technologies raise, as well as opportunities they provide for understanding development, evolution and disease.

By Joshua R. Sanes
29 January 2024 | 7 min read

Get notified every time a new column in this series is published.

Explore more from The Transmitter

Close-up of high-resolution fMRI images.

Functional MRI can do more than you think

Recent technological advances provide a range of new and different information about brain physiology. But taking full advantage of these gains depends on collaboration between engineers and neuroscientists.

By Laura Lewis
14 April 2025 | 6 min read
People help each other climb up a supersized human brain.

As federal funders desert mentorship programs for marginalized students, trainee-led initiatives fill the gap

Grassroots organizations, led by graduate students and postdoctoral researchers, are stepping up to provide neuroscience career training and guidance for students from marginalized backgrounds—and they need your support.

By Christian Cazares, Maribel Patiño
11 April 2025 | 5 min read
Research image of two mouse brain slices.

Split gene therapy delivers promise in mice modeling Dravet syndrome

The new approach overcomes viral packaging limitations by delivering SCN1A piecemeal and stitching it together in target cells.

By Holly Barker
10 April 2025 | 5 min read