Timothy O’Leary.

Timothy O’Leary

Professor of information engineering and neuroscience
University of Cambridge

Timothy O’Leary is professor of information engineering and neuroscience at the University of Cambridge. His research lies at the intersection between physiology, computation and control engineering. His goal is to understand how nervous systems self-organize, adapt and fail, and to connect these to diversity and variability in nervous system properties.

Originally trained as a pure mathematician, O’Leary dropped out of a Ph.D. on hyperbolic geometry to study the brain. After retraining as an experimental physiologist, he obtained his doctorate in experimental and computational neuroscience from the University of Edinburgh in 2009.

He has worked as both an experimentalist and theoretician, on systems that span the scale from single ion channel dynamics to whole brain and behavior, and across invertebrate and vertebrate species. His group works closely with experimentalists to study neuromodulation, neural dynamics and how sensorimotor information is represented in the brain, more recently focusing on how neural representations evolve over time. He approaches these problems from an unusual perspective, citing engineering principles as being key to understanding the brain—and biology more widely.

Explore more from The Transmitter

Image of squirrels on a branch.

NeuroAI and the hidden complexity of agency

As we attempt to build autonomous artificial-intelligence systems, we're discovering that a capability we take for granted in animals may be much more complex than we imagined.

By Anthony Zador
5 February 2025 | 6 min read

Plaque levels differ in popular Alzheimer’s mouse model depending on which parent’s variants are passed down

5XFAD model mice that inherit two disease-related genes from their fathers have double the plaques seen in those with maternal inheritance, a new study shows.

By Shaena Montanari
4 February 2025 | 0 min watch
The word Doctored spelled out on pills.

‘Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer’s,’ an excerpt

In his new book, published today, investigative journalist Charles Piller tells the story of the scientific misconduct that shook Alzheimer’s disease research to its core, and the neuroscientist who helped to expose it.

By Charles Piller
4 February 2025 | 9 min read