Carlo Cadenas
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Genome structure could be key factor in some forms of autism
Variants in DNA stretches that do not code for proteins may alter the genome’s 3D architecture, influencing the expression of distant genes linked to autism.

Genome structure could be key factor in some forms of autism
‘Polygenic risk scores’ for autism, explained
These scores — composite measures of a person’s autism-linked common genetic variants — cannot predict an autism diagnosis but could help researchers better understand the condition’s underlying biology.

‘Polygenic risk scores’ for autism, explained
‘Dosage sensitivity map’ predicts active ingredients in copy number variants
The catalog of rare copy number variants tied to autism and other conditions could help researchers identify which genes account for the mutations’ effects.

‘Dosage sensitivity map’ predicts active ingredients in copy number variants
Deletions on chromosome 22 have ripple effects across genome
Deletion of the 22q11.2 chromosomal region alters the expression of numerous autism- and schizophrenia-linked genes, most of which are not contained within the deleted region, a new study suggests.

Deletions on chromosome 22 have ripple effects across genome
The connection between oxytocin and autism, explained
Oxytocin, cemented in the popular imagination as the “love molecule,” could serve as a treatment for some autistic people who naturally have low levels of the hormone, researchers say.

The connection between oxytocin and autism, explained
Explore more from The Transmitter
Diving in with Nachum Ulanovsky
With an eye toward realism, the neuroscientist, who has a new study about bats out today, creates microcosms of the natural world to understand animal behavior.

Diving in with Nachum Ulanovsky
With an eye toward realism, the neuroscientist, who has a new study about bats out today, creates microcosms of the natural world to understand animal behavior.
Gene-activity map of developing brain reveals new clues about autism’s sex bias
Boys and girls may be vulnerable to different genetic changes, which could help explain why the condition is more common in boys despite linked variants appearing more often in girls.

Gene-activity map of developing brain reveals new clues about autism’s sex bias
Boys and girls may be vulnerable to different genetic changes, which could help explain why the condition is more common in boys despite linked variants appearing more often in girls.
Engrams in amygdala lean on astrocytes to solidify memories
Disrupting the astrocyte-neuronal dynamic in mice destabilizes their memory of fear conditioning.

Engrams in amygdala lean on astrocytes to solidify memories
Disrupting the astrocyte-neuronal dynamic in mice destabilizes their memory of fear conditioning.