Connectivity

Recent articles

Tatiana Engel explains how to connect high-dimensional neural circuitry with low-dimensional cognitive functions

Neuroscientists have long sought to understand the relationship between structure and function in the vast connectivity and activity patterns in the brain. Engel discusses her modeling approach to discovering the hidden patterns that connect the two.

By Paul Middlebrooks
3 December 2025 | 1 min read
A drosophila connectome.

One year of FlyWire: How the resource is redefining Drosophila research

We asked nine neuroscientists how they are using FlyWire data in their labs, how the connectome has transformed the field and what new tools they would like to see in the future.

By Francisco J. Rivera Rosario
7 October 2025 | 17 min read
Map of the fly nervous system.

Local circuit loops within body control fly behavior, new ‘embodied’ connectome reveals

The mapping, which traces how the central nervous system interacts with the rest of the body, challenges the idea that behavior control is centralized.

By Claudia López Lloreda
24 September 2025 | 5 min read
Research image of neuron organization in c elegans.

Worms help untangle brain structure/function mystery

The synaptic connectome of most animals bears little resemblance to functional brain maps, but it can still predict neuronal activity, according to two preprints that tackle the puzzle in C. elegans

By Holly Barker
29 August 2025 | 7 min read
A person enters an MRI machine.

Longer fMRI brain scans boost reliability—but only to a point

Around 30 minutes of imaging per person seems to be the “sweet spot” for linking functional connectivity differences to traits in an accurate and cost-effective way.

By Claudia López Lloreda
20 August 2025 | 5 min read
Illustration of synapse-like threads connecting in various ways.

Learning in living mice defies classic synaptic plasticity rule

Donald Hebb’s theory—memorably summarized as “cells that fire together, wire together”—does not explain the shifting hippocampal connections in mice learning to navigate a virtual environment, according to a new study.

By Sydney Wyatt
28 May 2025 | 5 min read
Research image showing resting-state functional connectivity in the human red nucleus.

‘Ancient’ brainstem structure evolved beyond basic motor control

The human red nucleus may also help coordinate action, reward and motivated behavior, a new study suggests.

By Sydney Wyatt
16 May 2025 | 5 min read
Research image of connectivity in the fly brain.

Connectomics 2.0: Simulating the brain

With a complete fly connectome in hand, researchers are taking the next step to model how brain circuits fuel function.

By Laura Dattaro
2 May 2025 | 10 min read
Research image of grids of mouse and human brain scans.

Too much or too little brain synchrony may underlie autism subtypes

Functional connectivity differences in autism mouse models point to two subtypes that correspond to patterns seen in some people with the condition.

By Calli McMurray
17 April 2025 | 5 min read
Detailed image of neurons in the mouse visual cortex.

Inhibitory cells work in concert to orchestrate neuronal activity in mouse brain

A cubic millimeter of brain tissue, meticulously sectioned, stained and scrutinized over the past seven years, reveals in stunning detail the role of inhibitory interneurons in brain structure and function.

By Katie Moisse
9 April 2025 | 6 min read

Explore more from The Transmitter

Research image of organoids derived from stem cell lines from people with intellectual disability, polymicroglia or microcephaly, alongside a control organoid.

New organoid atlas unveils four neurodevelopmental signatures

The comprehensive resource details data on microcephaly, polymicrogyria, epilepsy and intellectual disability from 352 people.

By Diana Kwon
17 December 2025 | 4 min read

Can neuroscientists decode memories solely from a map of synaptic connections?

Five experts discuss the progress, possibilities and hurdles of decoding a “nontrivial” memory from an organism just by analyzing its brain connectivity patterns.

By Paul Middlebrooks
17 December 2025 | 1 min read
A scientist chases falling code with a butterfly net in a spare landscape with beautiful high clouds.

AI-assisted coding: 10 simple rules to maintain scientific rigor

These guidelines can help researchers ensure the integrity of their work while accelerating progress on important scientific questions.

By Russell Poldrack
16 December 2025 | 7 min read

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