Computational neuroscience

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This series examines the latest advances and insights on the intersection between neuroscience and AI.

Textbook model of hippocampus’s role in memory may need updating

The CA3 region, long thought to have just one circuit, has two, sporting different wiring and functions, a new preprint suggests.

By Alissa de Chassey
4 August 2026 | 5 min read
A brain shape outlined in cylindrical dials with multi colored wires stretched between them.

Transforming AI models into useful model organisms

These systems were not built to explain the brain. But treating them as model organisms that we can perturb and evolve will move us closer to that goal.

By Mariya Toneva
22 June 2026 | 6 min read
Illustration of pixelated AI models.

Models at the speed of thought: How AI coding is reshaping theoretical neuroscience

Agentic coding makes it possible to specify a neuroscience model in hours instead of months. Seven neuroscientists weigh in on what that tectonic change may bring to the field.

By Brian DePasquale
16 June 2026 | 17 min read
Neural networks illustration.

This paper changed my life: Appreciating John Hopfield’s brilliant neural network

In a 1982 paper, the Nobel laureate created his namesake recurrent neural network—work that taught Maria Geffen to always ground research questions in biology.

By Maria Geffen
15 May 2026 | 5 min read
Illustration of a sheet of paper with a topography map-like pattern on it.

Why neural foundation models work, and what they might—and might not—teach us about the brain

These models can partly generalize across species, brain regions and tasks, suggesting that a set of machine-learnable rules govern neural population activity. But will we be able to understand them?

By Juan Gallego
13 April 2026 | 8 min read

Explore more from The Transmitter

Alison Barth discovers how different neuron types contribute to cortical function

Barth uses learning tasks in mice as a tool to drive synaptic plasticity in the sensory cortex, hoping to unlock more general principles of how the cortex works.

By Paul Middlebrooks
5 August 2026 | 1 min read
Mouse muscle cells.

Virus-like particles deliver gene-editing tools into Duchenne mouse model

The approach uses a protein found in fruit flies to ferry the gene editor Cas9 into muscle cells.

By Brianna Abbott
5 August 2026 | 5 min read
Single-cell spatial transcriptomics chart maps of cell types.

Using antisense oligos to plumb rare genetic conditions, and more

Here is a roundup of autism-related news and research spotted around the web for the week of 3 August.

By Jill Adams
4 August 2026 | 2 min read