Computational neuroscience

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This series examines the latest advances and insights on the intersection between neuroscience and AI.

Illustration of a sheet of paper with a topography map-like pattern on it.

Why neural foundation models work, and what they might—and might not—teach us about the brain

These models can partly generalize across species, brain regions and tasks, suggesting that a set of machine-learnable rules govern neural population activity. But will we be able to understand them?

By Juan Gallego
13 April 2026 | 8 min read
A fragmenting cube hovers over a person reading a book.

Error equation predicts brain’s ability to generalize

Four statistical measurements of neural network geometry capture how well brains and artificial networks use what they already know to solve new problems, a study suggests.

By Natalia Mesa
10 April 2026 | 5 min read

Romain Brette reveals fundamental flaws in commonly assumed neuroscience concepts

His new book, “The Brain, In Theory,” offers alternatives to many of the computer science frameworks currently driving theoretical neuroscience.

By Paul Middlebrooks
8 April 2026 | 131 min listen
Book cover of The Brain, In Theory by Romain Brette.

‘The Brain, In Theory,’ an excerpt

In his new book, Brette pushes back against theories that describe the brain as a “biological computer.” In this excerpt from Chapter 4, he challenges equating brain evolution with programming, and the universality of neural network models.

By Romain Brette
7 April 2026 | 5 min read
Kieth Hengen looks through a small window, aligning his face with a fancy moustache sticker and rolling his eyes comically to the side.

Computational neuroscientist Keith Hengen explains his work through illustrations

The images help him communicate the “big-picture ideas” behind the mathematical principles of neuronal networks.

By Helena Kudiabor
7 April 2026 | 4 min read

Explore more from The Transmitter

A large, abstract shape flows out of a small box.

Embrace complexity to improve the translatability of basic neuroscience

Researchers must learn to view heterogeneity as an essential feature of the systems they study and a central consideration in experimental design, not a variable to control for or reduce.

By Linda Douw, Klaus Eyer, Lara Keuck
9 April 2026 | 5 min read

Arboreal deer mice reveal neural roots of dexterity

The rodents offered researchers an opportunity to link genetically driven changes in corticospinal abundance and morphology to climbing cachet.

By Siddhant Pusdekar
8 April 2026 | 0 min watch
Research image of mice microglia.

Single-gene systems-level effects, and more

Here is a roundup of autism-related news and research spotted around the web for the week of 6 April.

By Jill Adams
7 April 2026 | 2 min read