Michael Ehlers
Neuroscience Chief Scientific Officer
Pfizer
From this contributor
A cautionary tale for autism drug development
Poorly designed animal drug studies for motor disorders have led to spurious conclusions for the clinical trials that follow. This may be even more true for autism research, says Michael Ehlers.
SHANK mutations converge at neuronal junctions in autism
SHANK3, one of the strongest candidate genes for autism, has the potential to be a molecular entry point into understanding the synaptic, developmental and circuit origins of the disorder.
SHANK mutations converge at neuronal junctions in autism
Drug zone
Rodent and stem cell models remain challenging for developing psychiatric drugs, says Michael Ehlers, chief scientific officer of neuroscience at Pfizer.
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Revisiting the neural correlates of consciousness
Life happens in real time, but experience may be composed in ragtime—like the music genre, full of offbeat notes and uneven rhythms. The assumption that waking life consists of a “stream” of conscious representations has inadvertently led consciousness science to its current impasse.
Revisiting the neural correlates of consciousness
Life happens in real time, but experience may be composed in ragtime—like the music genre, full of offbeat notes and uneven rhythms. The assumption that waking life consists of a “stream” of conscious representations has inadvertently led consciousness science to its current impasse.
Grant review needs reform. How about we add an element of chance?
A process that uses a lottery system saves time, reduces strategic resubmission and accepts that, above a quality threshold, luck has always played a part in science funding.
Grant review needs reform. How about we add an element of chance?
A process that uses a lottery system saves time, reduces strategic resubmission and accepts that, above a quality threshold, luck has always played a part in science funding.
Fly neurons carry molecular signatures of their origins
The pattern of transcription factors a Drosophila neuron expresses offers clues to its lineage and birth order—and ultimately how neural circuits emerge.
Fly neurons carry molecular signatures of their origins
The pattern of transcription factors a Drosophila neuron expresses offers clues to its lineage and birth order—and ultimately how neural circuits emerge.