ASHG 2019

Recent articles

RNA, transcription

Antidote to ‘poison’ DNA may treat lethal form of epilepsy

An experimental drug silences a DNA segment and seems to prevent seizures and death in a condition related to autism.

By Nicholette Zeliadt
26 August 2020 | 3 min read

Brain ‘organoids’ point to new drug target for fragile X syndrome

New findings hint at why drugs that work in mouse models of fragile X syndrome have not been effective in people.

By Nicholette Zeliadt
18 October 2019 | 3 min read
Illustration of a DNA strand.

Massive project doubles list of genes tied to autism

The largest analysis of sequences from autistic people and their families implicates 184 genes in the condition — nearly doubling the previous estimate.

By Nicholette Zeliadt
17 October 2019 | 3 min read

Explore more from The Transmitter

Neuronal genes SATB2 and MEF2C.

Nuclear location helps control gene activity during brain development

A study of developing human brain tissue suggests that genes switch on more strongly when they move from the nucleus’s edge toward structures that contain proteins involved in making and processing RNA.

By Giorgia Guglielmi
20 August 2026 | 4 min read
Cortical organoids.

Five-year-old human brain organoids aged on schedule

The cultured spheres typically mimic only prenatal development, but the five-year-old ones grown in Paola Arlotta’s lab acquired postnatal features.

By Claudia López Lloreda
19 August 2026 | 5 min read