Amyloid beta

Recent articles

Plaque levels differ in popular Alzheimer’s mouse model depending on which parent’s variants are passed down

5XFAD model mice that inherit two disease-related genes from their fathers have double the plaques seen in those with maternal inheritance, a new study shows.

By Shaena Montanari
4 February 2025 | 0 min watch
Six different neurons.

Early trajectory of Alzheimer’s tracked in single-cell brain atlases

Inflammation in glia and the loss of certain inhibitory cells may kick off a disease cascade decades before diagnosis.

By Angie Voyles Askham
23 October 2024 | 8 min read
Colored transmission electron micrograph (TEM) showing an amyloid plaque in a brain with Alzheimer’s disease.

Skeptics challenge claims of Alzheimer’s disease transmission via growth hormone

Some people who received cadaver-derived human growth hormone may not have Alzheimer’s as previously suggested, according to a new Perspective article.

By Shaena Montanari
23 August 2024 | 6 min read
Research image of green and purple mouse brain slices.

Putting a bright idea to the test

A surprising wave of findings in mice suggests that light and sound flickering at 40 hertz clears the brain of Alzheimer’s-disease-linked plaques. Several companies are hoping to prove it works in people.

By Shaena Montanari
21 August 2024 | 11 min read
Image of amyloid beta plaques.

Reviving ‘inside-out’ hypothesis of amyloid beta to explain Alzheimer’s mysteries

New research is resurfacing old ideas about where the protein forms the disease’s hallmark plaques.

By Elissa Welle
29 May 2024 | 9 min listen
Picture of two Degus in a cage.

How inbreeding almost tanked an up-and-coming model of Alzheimer’s disease

But new genetic analyses and behavioral assays have made the Chilean degu a viable model again, researchers say.

By Calli McMurray
21 May 2024 | 10 min read
Photograph of Carol Jennings.

Carol Jennings, whose family’s genetics informed amyloid cascade hypothesis, dies at 70

Her advocacy work aided the discovery of a rare inherited form of early-onset Alzheimer’s disease and helped connect affected people with researchers.

By Elissa Welle
30 April 2024 | 4 min listen

Explore more from The Transmitter

Coins flow from a spigot.

Newly awarded NIH grants for neuroscience lag 77 percent behind previous nine-year average

Since President Donald Trump took office on 20 January, the National Institute of Neurological Disease and Stroke and the National Institute of Mental Health have awarded one quarter as many new grants as during the same two-month period, on average, since 2016.

By Natalia Mesa
4 April 2025 | 5 min read
Raphael Yuste leaning on a bench in his lab. A red filter colors the scene.

Releasing the Hydra with Rafael Yuste

Losing HHMI Investigator status prompted Yuste to study neural networks in a new way.

By Brady Huggett, Shaena Montanari
4 April 2025 | 10 min read
Glitchy image of a stamp.

Coding error caused layoffs at National Institute of Neurological Disorders and Stroke this week, source says

Thirty employees—including 11 lab heads—at the institute should “immediately return to work,” according to an email the institute’s Office of Human Resources sent to top administration at the institute Wednesday evening.

By Sydney Wyatt
3 April 2025 | 3 min read