Graphic resembling a topographical map.

What is the state of neuroscience?

In this 2025 special report, The Transmitter surveys the research landscape: How is basic neuroscience changing, and where do its practitioners think it is headed?

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Today’s action potentials

NEW RESEARCH
A new atlas provides high-resolution, 3D maps of the early postnatal mouse brain and reveals “region-specific density changes in [GABAergic] neurons, cortical layer-specific cell types, and microglia as key players in shaping early postnatal brain development.”
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QUOTE

That means that not only shouldn’t we trust results from studies with 10 or 20 people, we should ignore them. They’re just noise. — KEVIN MITCHELL, ASSOCIATE PROFESSOR OF GENETICS AND NEUROSCIENCE, TRINITY COLLEGE IN DUBLIN

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NEW PREPRINT
A. Rother et al. have constructed the first vertebrate basal ganglia connectome by mapping circuits in a zebra finch; their data “challenge the universality of the view of the basal ganglia as an information processor organized into discrete feedforward pathways.”
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Spectrum logo
Illustration of a neuron.

New questions around motor neurons and plasticity

A researcher’s theory hangs muscle degeneration on a broken neural circuit.

By David Adam
10 October 2025 | 9 min read
Judit Pungor and Angelique Allen stand in front of a saltwater tank.
Vision Microphone

Cephalopods, vision’s next frontier

For decades, scientists have been teased by the strange but inaccessible cephalopod visual system. Now, thanks to a technological breakthrough from a lab in Oregon, data are finally coming straight from the octopus brain.

By Calli McMurray
27 May 2025 | 13 min read
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Composite of headshots of researchers who opened new labs in the past several years.
Community

The Transmitter’s New Lab Directory

By Francisco J. Rivera Rosario
15 November 2025 | 21 min read
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A drosophila connectome.

One year of FlyWire: How the resource is redefining Drosophila research

We asked nine neuroscientists how they are using FlyWire data in their labs, how the connectome has transformed the field and what new tools they would like to see in the future.

By Francisco J. Rivera Rosario
7 October 2025 | 17 min read
Illustration of a hand drawing lines between different points on the outline of a brain.

Beyond Newtonian causation in neuroscience: Embracing complex causality

The traditional mechanistic framework must give way to a richer understanding of how brains actually generate behavior over time.

By Luiz Pessoa
22 September 2025 | 20 min read
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