Transcriptomics

Recent articles

Six different neurons.

Early trajectory of Alzheimer’s tracked in single-cell brain atlases

Inflammation in glia and the loss of certain inhibitory cells may kick off a disease cascade decades before diagnosis.

By Angie Voyles Askham
23 October 2024 | 8 min read

Octopus arm anatomy, molecular makeup revealed in new maps

The datasets provide “a very nice reference” for future functional studies.

By Calli McMurray
25 September 2024 | 1 min watch
-A playful “cellular map” features top-down and bottom-up views of the human brain arranged side-by-side as if they were the earth’s two hemispheres in an old-fashioned map of the world. The brains are colored to suggest land masses and bodies of water.

Knowledge graphs can help make sense of the flood of cell-type data

These tools, widely used in the technology industry, could provide a foundation for the study of brain circuits.

By Michael Hawrylycz
28 May 2024 | 7 min read
Illustration of neurons against a blue background.

Where do cell states end and cell types begin?

High-throughput transcriptomics offers powerful new methods for defining different types of brain cells. But we need to think more explicitly about how we use these data to distinguish a cell’s permanent identity from its transient states.

By Anne E. West
22 April 2024 | 6 min read
An illustration of a gold circle and wavy blue plants.

Building a brain: How does it generate its exquisite diversity of cells?

High-throughput technologies have revealed new insights into how the brain develops. But a truly comprehensive map of neurodevelopment requires further advances.

By Tomasz Nowakowski, Karthik Shekhar
18 March 2024 | 6 min read
A diagram of many types of cells

Welcome to the second single-cell revolution: New high-throughput technologies are transforming how we define neurons

This ongoing essay series will explore questions these technologies raise, as well as opportunities they provide for understanding development, evolution and disease.

By Joshua R. Sanes
29 January 2024 | 7 min read
A figure walks along a long road with a gene-sequence-like pattern.

How long-read sequencing will transform neuroscience

New technology that delivers much more than a simple DNA sequence could have a major impact on brain research, enabling researchers to study transcript diversity, imprinting and more.

By Tychele Turner
22 November 2023 | 7 min listen

Explore more from The Transmitter

A repeating pattern of orange butterflies against a blue background.

‘Huge influx’ of neuroscientists migrates to Bluesky

Daily neuroscience-related posts on the social-media platform this week have increased more than 400 percent, on average, compared with October.

By Calli McMurray
21 November 2024 | 5 min read
Woman in a clinician's office.

Autism prevalence increasing in children, adults, according to electronic medical records

The uptick from 2011 to 2022 in the United States underscores a need for more services and research, the investigators say.

By Shaena Montanari
21 November 2024 | 2 min read
Research image of mouse cells.

Immune cell interlopers breach—and repair—brain barrier in mice

The choroid plexus, the protective network of blood vessels and epithelial cells that line the brain’s ventricles, recruits neutrophils and macrophages during inflammation, a new study shows.

By Claudia López Lloreda
20 November 2024 | 6 min read