Systems neuroscience

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Psilocybin rewires specific mouse cortical networks in lasting ways

Neuronal activity induced by the psychedelic drug strengthens inputs from sensory brain areas and weakens cortico-cortical recurrent loops.

By Siddhant Pusdekar
5 December 2025 | 0 min watch
Illustration of a group of neurons.

This paper changed my life: Nancy Padilla-Coreano on learning the value of population coding

The 2013 Nature paper by Mattia Rigotti and his colleagues revealed how mixed selectivity neurons—cells that are not selectively tuned to a stimulus—play a key role in cognition.

By Nancy Padilla-Coreano
1 December 2025 | 5 min read
Two bouncing balls.

What are the fastest-growing areas in neuroscience?

Respondents pointed to computational neuroscience, systems neuroscience, neuroimmunology and neuroimaging, among other subfields.

By The Transmitter
15 November 2025 | 6 min read
Collage illustration of a brain, people looking at the brain, and geometric shapes.

Neuroscience needs engineers—for more reasons than you think

Adopting an engineering mindset will help the field focus its research priorities.

By Timothy O’Leary
3 November 2025 | 8 min read
Illustration of a series of floating pools of water overflowing into each other.

The missing half of the neurodynamical systems theory

Bifurcations—an underexplored concept in neuroscience—can help explain how small differences in neural circuits give rise to entirely novel functions.

By Xiao-Jing Wang
27 October 2025 | 8 min read

Explore more from The Transmitter

Illustration of a simple circuit.

Not playing around: Why neuroscience needs toy models

Amid the rise of billion-parameter models, I argue that toy models, with just a few neurons, remain essential—and may be all neuroscience needs.

By Marcus Ghosh
22 December 2025 | 6 min read
A mouse stands on a gloved hand.

Psychedelics research in rodents has a behavior problem

Simple behavioral assays—originally validated as drug-screening tools—fall short in studies that aim to unpack the psychedelic mechanism of action, so some behavioral neuroscientists are developing more nuanced tasks.

By Calli McMurray
19 December 2025 | 8 min read
Research image of organoids derived from stem cell lines from people with intellectual disability, polymicroglia or microcephaly, alongside a control organoid.

New organoid atlas unveils four neurodevelopmental signatures

The comprehensive resource details data on microcephaly, polymicrogyria, epilepsy and intellectual disability from 352 people.

By Diana Kwon
17 December 2025 | 4 min read

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