Systems neuroscience

Recent articles

High-resolution image of interconnected brain cells highlighted in magenta and blue.

What are recurrent networks doing in the brain?

The cortex is filled with excitatory local synapses, but we know little about their role in brain function. New experimental tools, along with ideas from artificial intelligence, are poised to change that.

By Mark Histed
16 December 2024 | 5 min read
Illustration of a person holding a box that is emitting laser-like beams and projecting a large curved black surface.

Imagining the ultimate systems neuroscience paper

A growing body of papers on systems neuroscience and on giant simulations of neural circuits involves data beyond the point that anyone can reasonably understand end to end. Looking ahead, “paper-bots” could solve that problem.

By Mark Humphries
2 December 2024 | 8 min read
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How to be a multidisciplinary neuroscientist

Neuroscience subfields are often siloed. Embracing an integrative approach during training can help change that.

By Austin Coley
15 November 2024 | 5 min read
Research image of mouse brain scans.

Widely distributed brain areas sync to orchestrate decisions in rodents

Multiple brain areas synchronize their activity to help a rodent accumulate the evidence it needs to make a choice, two new studies suggest.

By Claudia López Lloreda
29 October 2024 | 7 min read
Illustration of an image of a landscape repeated over and over again, with some versions distorted and warped.

What makes memories last—dynamic ensembles or static synapses?

Teasing out how different subfields conceptualize central terms might help move this long-standing debate forward. I asked eight scientists to weigh in.

By Jason Shepherd
14 October 2024 | 7 min read
Illustration of a mouse with cheese on its left and a drop of water on its right.

Should I stay (and eat) or should I go? How the brain balances hunger with competing drives

Understanding the interplay among rival signals, such as pain, thirst and fear, could provide insights into anxiety and other neuropsychiatric conditions.

By Giorgia Guglielmi
11 October 2024 | 8 min read
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Cristina Savin and Tim Vogels discuss how AI has shaped their neuroscience research

Not all neuroscientists use artificial intelligence in the same way or for the same purpose. Neuroscience researchers from different fields discuss the impact AI has had on their research and how it influences productivity in their labs.

By Paul Middlebrooks
11 October 2024 | 80 min listen
Licorice and red candy against a lavender background.

Double-duty neurons in primary olfactory cortex pick up on more than just scent

The cells recognize not only odors, such as bananas and black licorice—but also images and words associated with those smells, according to single-neuron recordings from 17 people.

By Angie Voyles Askham
9 October 2024 | 7 min read
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Kenneth Harris and Andreas Tolias explain how AI has informed their neuroscience research

Modern AI models have shaped how the pair thinks about our brains and minds, asks research questions and views scientific progress and productivity.

By Paul Middlebrooks
8 October 2024 | 77 min listen
Collage of different images of brains and mechanical devices in the background with a suitcase in the foreground.

What are mechanisms? Unpacking the term is key to progress in neuroscience

Mechanism is a common and powerful concept, invoked in grant calls and publication guidelines. But scientists use it in different ways, making it difficult to clarify standards in the field. We asked nine scientists to weigh in.

By Dani S. Bassett, Lauren N. Ross
7 October 2024 | 5 min read

Explore more from The Transmitter

Illustration of a shrew, sandpiper, locust, axolotl, monarch butterfly, African killifish, naked mole rat, octopus, bat and cichlid.

The non-model organism “renaissance” has arrived

Meet 10 neuroscientists bringing model diversity back with the funky animals they study.

Assembloids illuminate circuit-level changes linked to autism, neurodevelopment

These complex combinations of organoids afford a closer look at how gene alterations affect certain brain networks.

By Sarah DeWeerdt
19 December 2024 | 0 min watch
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Rajesh Rao reflects on predictive brains, neural interfaces and the future of human intelligence

Twenty-five years ago, Rajesh Rao proposed a seminal theory of how brains could implement predictive coding for perception. His modern version zeroes in on actions.

By Paul Middlebrooks
18 December 2024 | 97 min listen