Synaptic vesicles

Recent articles

Abstract illustration of a synaptic vesicle.

This paper changed my life: Sandra Jurado marvels at the first-ever 3D model of a synaptic vesicle

In this 2006 Cell paper, Shigeo Takamori and his colleagues showcased the molecular machinery of synaptic vesicles in outstanding detail. Their work taught me that these aren’t just passive containers for neurotransmitters but dynamic, precision-built nanomachines.

By Sandra Jurado
21 October 2025 | 5 min read
Illustrated portrait of Tim Ryan.

Timothy Ryan on his pivotal switch from studying particle physics to decoding synaptic transmission

Dissuaded from pursuing theoretical physics and deterred by the “long feedback loop” in experimental physics, the National Academy of Sciences member took inspiration from “polymath” Watt Webb and “visionary” Stephen Smith—and learned to work “completely outside his comfort zone.”

By Brady Huggett
1 October 2024 | 70 min listen
lllustration of the junction between two nerve cells.

Multi-omics study captures CNTNAP2’s far-ranging effects

The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.

By Charles Q. Choi
8 December 2022 | 4 min read
Oil and water with colors behind: blue, green, yellow and red.

How microscopic ‘condensates’ in cells might contribute to autism

A controversial idea about how cells compartmentalize their contents into droplets — like beads of oil in water — could be key to understanding autism, says Julie Forman-Kay.

By Angie Voyles Askham
23 February 2021 | 7 min read

New method exposes structures inside ‘rainbow’ of brain cells

Molecules from alpacas may enable scientists to identify cell types in the brain while also revealing their interior structures.

By Chloe Williams
4 January 2019 | 0 min watch

Dividing autism; novel messengers; million-dollar mark and more

A researcher proposes splitting autism into subtypes, mitochondria make neurotransmitters, and highly successful grantees may face a funding cap.

By Emily Willingham
11 May 2018 | 3 min read

New tool spotlights neuron junctions in living human brains

A new imaging technique allows researchers to illuminate the junctions between neurons in a living person’s brain.

By Rachel Zamzow
19 August 2016 | 2 min read
Spectrum from The Transmitter.

Rainbow of dyes maps neurons’ tangled paths in brain

A new method that lets researchers trace the paths of many neurons at once may reveal how neurons go astray in autism.

By Kate Yandell
13 May 2015 | 3 min read
Spectrum from The Transmitter.

Suite of methods yields complex model of neuronal junctions

Researchers debuted a three-dimensional model of an average synapse, the point of connection between neurons, in the 30 May issue of Science.

By Kate Yandell
2 July 2014 | 2 min read
Spectrum from The Transmitter.

Molecular mechanisms: Autism gene establishes brain links

The autism-linked protein MET is expressed at the junctions between neurons during early brain development in mice, suggesting that it helps establish the connections, according to a study published 21 June in The Journal of Comparative Neurology.

By Jessica Wright
27 August 2013 | 2 min read

Explore more from The Transmitter

Illustration of a circuit made of sperm-like lines.

Gene variants accumulate in older men’s sperm; and more

Here is a roundup of autism-related news and research spotted around the web for the week of 20 October.

By Jill Adams
21 October 2025 | 2 min read
A worm made of circuitry.

Whole-brain, bottom-up neuroscience: The time for it is now

Applying new tools to entire brains, starting with C. elegans, offers the opportunity to uncover how molecules work together to generate neural physiology and how neurons work together to generate behavior.

By Edward Boyden, Konrad Körding
20 October 2025 | 9 min read
Collage of fruit fly and money.

Fly database secures funding for another year, but future remains in flux

The FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.

By Calli McMurray
17 October 2025 | 3 min read

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