Single-cell sequencing
Recent articles
Expanding set of viral tools targets almost any brain cell type
Harmless viruses that encase short noncoding DNA elements called enhancers enable cell-type-specific gene delivery across the central nervous system in rodents and primates.
Expanding set of viral tools targets almost any brain cell type
Harmless viruses that encase short noncoding DNA elements called enhancers enable cell-type-specific gene delivery across the central nervous system in rodents and primates.
START method assembles brain’s wiring diagram by cell type
The new technique mapped the interactions of about 50 kinds of inhibitory neurons in the mouse visual cortex in finer detail than previous approaches.
START method assembles brain’s wiring diagram by cell type
The new technique mapped the interactions of about 50 kinds of inhibitory neurons in the mouse visual cortex in finer detail than previous approaches.
Early trajectory of Alzheimer’s tracked in single-cell brain atlases
Inflammation in glia and the loss of certain inhibitory cells may kick off a disease cascade decades before diagnosis.
Early trajectory of Alzheimer’s tracked in single-cell brain atlases
Inflammation in glia and the loss of certain inhibitory cells may kick off a disease cascade decades before diagnosis.
Supersized version of Alzheimer’s protein avoids clumping in brain
“Big tau” may explain why some brain regions, such as the cerebellum and brainstem, are largely spared from neurodegeneration, even though tau is expressed throughout the nervous system.
Supersized version of Alzheimer’s protein avoids clumping in brain
“Big tau” may explain why some brain regions, such as the cerebellum and brainstem, are largely spared from neurodegeneration, even though tau is expressed throughout the nervous system.
As circuits wire up, interneurons take cues from surrounding cells
The inhibitory cells’ development, diversity and abundance in the cortex is directed in part by pyramidal cells, a new preprint suggests.
As circuits wire up, interneurons take cues from surrounding cells
The inhibitory cells’ development, diversity and abundance in the cortex is directed in part by pyramidal cells, a new preprint suggests.
Giant analysis reveals how autism-linked genes affect brain cell types
Genes that predispose people to autism account for a large portion of the neuronal and glial cell changes seen in those with the condition.
Giant analysis reveals how autism-linked genes affect brain cell types
Genes that predispose people to autism account for a large portion of the neuronal and glial cell changes seen in those with the condition.
Autism-linked perturbations converge on cell skeleton and RNA-binding proteins
The findings solidify the idea that autism-linked mutations affect brain activity by way of several key shared mechanisms.
Autism-linked perturbations converge on cell skeleton and RNA-binding proteins
The findings solidify the idea that autism-linked mutations affect brain activity by way of several key shared mechanisms.
Vast diversity of human brain cell types revealed in trove of new datasets
The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.
Vast diversity of human brain cell types revealed in trove of new datasets
The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.
Multi-omics study captures CNTNAP2’s far-ranging effects
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
Multi-omics study captures CNTNAP2’s far-ranging effects
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
Autism brain signature most pronounced in sensory areas
An analysis of 11 cortical regions shows anterior-to-posterior shifts in gene expression linked to autism.
Autism brain signature most pronounced in sensory areas
An analysis of 11 cortical regions shows anterior-to-posterior shifts in gene expression linked to autism.
Explore more from The Transmitter
Autism prevalence increasing in children, adults, according to electronic medical records
The uptick from 2011 to 2022 in the United States underscores a need for more services and research, the investigators say.
Autism prevalence increasing in children, adults, according to electronic medical records
The uptick from 2011 to 2022 in the United States underscores a need for more services and research, the investigators say.
Immune cell interlopers breach—and repair—brain barrier in mice
The choroid plexus, the protective network of blood vessels and epithelial cells that line the brain’s ventricles, recruits neutrophils and macrophages during inflammation, a new study shows.
Immune cell interlopers breach—and repair—brain barrier in mice
The choroid plexus, the protective network of blood vessels and epithelial cells that line the brain’s ventricles, recruits neutrophils and macrophages during inflammation, a new study shows.
Executive function; screen time; Rett syndrome therapy
Here is a roundup of autism-related news and research spotted around the web for the week of 18 November.
Executive function; screen time; Rett syndrome therapy
Here is a roundup of autism-related news and research spotted around the web for the week of 18 November.