Simons Simplex Collection
Recent articles
Untangling biological threads from autism’s phenotypic patchwork reveals four core subtypes
People belonging to the same subtype share genetic variants, behaviors and often co-occurring diagnoses, according to a new preprint.
Untangling biological threads from autism’s phenotypic patchwork reveals four core subtypes
People belonging to the same subtype share genetic variants, behaviors and often co-occurring diagnoses, according to a new preprint.
Genome structure could be key factor in some forms of autism
Variants in DNA stretches that do not code for proteins may alter the genome’s 3D architecture, influencing the expression of distant genes linked to autism.
Genome structure could be key factor in some forms of autism
Variants in DNA stretches that do not code for proteins may alter the genome’s 3D architecture, influencing the expression of distant genes linked to autism.
Some who lack autism diagnosis carry variants tied to the condition
The variants are associated with slight differences in measures of intelligence, income and employment, but the relationship may not be causal.
Some who lack autism diagnosis carry variants tied to the condition
The variants are associated with slight differences in measures of intelligence, income and employment, but the relationship may not be causal.
Null and Noteworthy: Modified MRI; father findings
This month’s newsletter tackles null findings from an attempted replication of a “revolutionary” MRI approach and an analysis of family genetics.
Null and Noteworthy: Modified MRI; father findings
This month’s newsletter tackles null findings from an attempted replication of a “revolutionary” MRI approach and an analysis of family genetics.
X-chromosome variants help explain autism’s sex bias
The rare variants are also linked to ADHD and Tourette syndrome, two other conditions that disproportionately affect boys and men.
X-chromosome variants help explain autism’s sex bias
The rare variants are also linked to ADHD and Tourette syndrome, two other conditions that disproportionately affect boys and men.
Scans of sundry variant types uncover autism-linked genes
Troves of sequencing data reveal genes tied to autism through different variant types, providing a more complete picture of the condition’s genetic roots and new clues to its heterogeneity.
Scans of sundry variant types uncover autism-linked genes
Troves of sequencing data reveal genes tied to autism through different variant types, providing a more complete picture of the condition’s genetic roots and new clues to its heterogeneity.
Mutations disrupting chromatin interactions contribute to autism
The mutations occur spontaneously in noncoding stretches of DNA that control gene expression.
Mutations disrupting chromatin interactions contribute to autism
The mutations occur spontaneously in noncoding stretches of DNA that control gene expression.
The final frontier: Autism geneticists take on the noncoding genome
The vast stretches of DNA that don't code for proteins could fill key knowledge gaps about autism genetics. But making sense of it all won't be easy.
The final frontier: Autism geneticists take on the noncoding genome
The vast stretches of DNA that don't code for proteins could fill key knowledge gaps about autism genetics. But making sense of it all won't be easy.
Common inherited variants tied to autism show sex bias in families
Siblings of autistic females are more likely to have autism than siblings of autistic males are, and mothers of autistic children carry more common, autism-linked variants than fathers do.
Common inherited variants tied to autism show sex bias in families
Siblings of autistic females are more likely to have autism than siblings of autistic males are, and mothers of autistic children carry more common, autism-linked variants than fathers do.
Spectrum of variants contribute differently to autism traits
Different combinations of common, rare, inherited and spontaneous mutations may explain why traits vary so widely among autistic people.
Spectrum of variants contribute differently to autism traits
Different combinations of common, rare, inherited and spontaneous mutations may explain why traits vary so widely among autistic people.
Explore more from The Transmitter
Cerebellar SHANK3; telehealth coaching for caregivers; psychedelics
Here is a roundup of autism-related news and research spotted around the web for the last two weeks of December.
Cerebellar SHANK3; telehealth coaching for caregivers; psychedelics
Here is a roundup of autism-related news and research spotted around the web for the last two weeks of December.
My hope for displaced Ukrainian children with autism, an update
The largest ongoing refugee crisis in Europe has overwhelmed humanitarian agencies. Meeting the needs of families affected by autism has not been a priority.
My hope for displaced Ukrainian children with autism, an update
The largest ongoing refugee crisis in Europe has overwhelmed humanitarian agencies. Meeting the needs of families affected by autism has not been a priority.
The Transmitter’s favorite essays and columns of 2024
From sex differences in Alzheimer’s disease to enduring citation bias, experts weighed in on important scientific and practical issues in neuroscience.
The Transmitter’s favorite essays and columns of 2024
From sex differences in Alzheimer’s disease to enduring citation bias, experts weighed in on important scientific and practical issues in neuroscience.