SCN2A
Recent articles
Widely used calcium imaging protocol can lead to spurious results, new paper cautions
The technique, which measures calcium currents as a proxy for neuronal firing, sometimes reports unusual and potentially misleading waves of activity in the hippocampus.
Widely used calcium imaging protocol can lead to spurious results, new paper cautions
The technique, which measures calcium currents as a proxy for neuronal firing, sometimes reports unusual and potentially misleading waves of activity in the hippocampus.
CRISPR gives autism-linked genes a boost, rescues functioning
A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.
CRISPR gives autism-linked genes a boost, rescues functioning
A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Mutation in top autism-linked gene may alter eye reflex
The discovery could help clinicians diagnose children who carry mutations in the gene, called SCN2A, and gauge their responses to potential therapies.
Mutation in top autism-linked gene may alter eye reflex
The discovery could help clinicians diagnose children who carry mutations in the gene, called SCN2A, and gauge their responses to potential therapies.
Top autism-linked genes join forces to shape synaptic plasticity
The protein products of ANK2 and SCN2A interact to regulate dendritic excitability.
Top autism-linked genes join forces to shape synaptic plasticity
The protein products of ANK2 and SCN2A interact to regulate dendritic excitability.
Autism research hits the road
Some scientists are thinking creatively about how to collect data in flexible environments and meet communities where they’re at.
Autism research hits the road
Some scientists are thinking creatively about how to collect data in flexible environments and meet communities where they’re at.
Latest ‘prime-editing’ tools tackle delivery, safety issues
The gene-editing advances make it easier to target specific tissues in mice and detect off-target effects.
Latest ‘prime-editing’ tools tackle delivery, safety issues
The gene-editing advances make it easier to target specific tissues in mice and detect off-target effects.
New evidence hints at mechanisms for ‘fever effect’ in autism
The temporary easing of traits that a minority of autistic children are reported to show during or after a fever may stem from a rise in body temperature.
New evidence hints at mechanisms for ‘fever effect’ in autism
The temporary easing of traits that a minority of autistic children are reported to show during or after a fever may stem from a rise in body temperature.
Dispatches from SfN 2021: Mitochondria, Rett therapy and oxytocin
These short reports from Spectrum journalists highlight some of the autism-related findings that caught our attention at the meeting this past week.
Dispatches from SfN 2021: Mitochondria, Rett therapy and oxytocin
These short reports from Spectrum journalists highlight some of the autism-related findings that caught our attention at the meeting this past week.
Reversing mutations in top autism-linked gene makes adult mice more social
Treatments that counteract the effects of an SCN2A mutation in mice increase the animals’ sociability in adulthood, according to a new unpublished study.
Reversing mutations in top autism-linked gene makes adult mice more social
Treatments that counteract the effects of an SCN2A mutation in mice increase the animals’ sociability in adulthood, according to a new unpublished study.
Explore more from The Transmitter
Rajesh Rao reflects on predictive brains, neural interfaces and the future of human intelligence
Twenty-five years ago, Rajesh Rao proposed a seminal theory of how brains could implement predictive coding for perception. His modern version zeroes in on actions.
Rajesh Rao reflects on predictive brains, neural interfaces and the future of human intelligence
Twenty-five years ago, Rajesh Rao proposed a seminal theory of how brains could implement predictive coding for perception. His modern version zeroes in on actions.
In memoriam: Yves Frégnac, influential and visionary French neuroscientist
Frégnac, who died on 18 October at the age of 73, built his career by meeting neuroscience’s complexity straight on.
In memoriam: Yves Frégnac, influential and visionary French neuroscientist
Frégnac, who died on 18 October at the age of 73, built his career by meeting neuroscience’s complexity straight on.
Explaining ‘the largest unexplained number in brain science’: Q&A with Markus Meister and Jieyu Zheng
The human brain takes in sensory information roughly 100 million times faster than it can respond. Neuroscientists need to explore this perceptual paradox to better understand the limits of the brain, Meister and Zheng say.
Explaining ‘the largest unexplained number in brain science’: Q&A with Markus Meister and Jieyu Zheng
The human brain takes in sensory information roughly 100 million times faster than it can respond. Neuroscientists need to explore this perceptual paradox to better understand the limits of the brain, Meister and Zheng say.